objective(s): systemic lupus erythematosus (sle) is a multi-factorial autoimmune disease which may be characterized by t lymphocytes dysfunctions. th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. in recent years, immunomodulatory effect of vitamin d3 has been noticed. in the present experiment, the effect of vitamin d3 on the expression of...

isolated hematuria and its association with proteinuria, and urinary cast and systemic lupus erythematosus (sle) disease activity, and decision for renal biopsy is a dilemma for physician in sle patients. the aim of this study was to investigate 1. whether isolated hematuria is associated with active sle, 2. to determine duration between hematuria and proteinuria and urinary cast, and 3. to det...

aim and background: systemic lupus erythematosus (sle) is a chronic autoimmune disease usually associated with high levels of pain and impairment in different systems, producing high levels of stress in patients who suffer from it. the purpose of this study was to consider the effectiveness of cognitive-behavioral stress management (cbsm) therapy on stress of female patients with sle. methods a...

Nocardiosis is a rare infection that in more frequent in patients with systemic lupus Erythematosus and its clinical manifestations are nonspecific.while concurrent treatment by corticosteroids is an independent risk factor for nocardiosis it increases both diagnostic and mangement problems.this article presents a 35 years old woman who has systemic lupus Erythematosus.she was hospitalized due ...

BACKGROUND Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects different end organs, including skin and brain. We and others have previously shown the importance of macrophages in the pathogenesis of cutaneous and neuropsychiatric lupus. Additionally, autoantibodies produced by autoreactive B cells are thought to play a role in both the skin and central nervous syst...

OBJECTIVE The aim of our study was to determine the volume of pathological foci in the brain tissue of patients suffering from systemic lupus erythematosus (SLE) with or without neuropsychiatric manifestations (NP), and also to find out if that volume depends on the study subjects' data and clinical records. Magnetic resonance (MR) scans of patients with SLE and, in particular, signs of neurops...

ANA: antinuclear antibody BID: twice a day CLE: cutaneous lupus erythematosus DIL: drug-induced lupus SLE: systemic lupus erythematosus INTRODUCTION Cutaneous lupus erythematosus (CLE), defined as isolated cutaneous lesions without significant systemic involvement, has a reported incidence and prevalence of 4.3 and 73.2 per 100,000, respectively. It occurs more commonly among women with a repor...

The lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders (mixed connective tissue disease, systemic vasculitis, polyarteritis nodosa, primary sicca syndrome, discoid lupus, Behcet's syndrome, and systemic sclerosis). Strong associations were found with biological false positive seroreaction for syphilis and thro...