Neuropeptide Y exists in the central nervous system as a co-transmitter, neuromodulator and neurohormone. It effects many processes dependent on the central nervous system. The paper reviews the latest knowledge on the structure and occurrance ofneuropeptide Y, its receptors, agonist and antagonist binding of these receptors. Taking into account its role in psychiatry, the authors concentrated ...

Neuropeptide Y (NPY) is a biologically active neuropeptide that responsible for large list of physiological processes. We propose short modified fragment NPY should at least partially have spectrum biological activity the original peptide. The compound was named nonapeptide NP9.
 aim our study to investigate ability influence spatial memory and learning.
 Materials methods: performed ...

Neuropeptide Y (NPY) has prominent cardiovascular effects in mammals and sharks, but no such effect has previously been demonstrated in any teleost fish. In the Atlantic cod, we found that cod NPY (10(-10)-10(-6) M) relaxed celiac arteries precontracted with epinephrine, and weak contractions were elicited in intestinal ring preparations. A few NPY-immunoreactive nerve fibers were present along...

OBJECTIVES This study aimed to investigate the alteration of Neuropeptide Y (NPY) in the hypothalamus and its correlation with insulin, leptin and ghrelin during the development of a rat model of type 2 diabetes mellitus. METHODS The type 2 diabetes mellitus model was developed in diet-induced obesity (DIO) rats followed by the intraperitoneal injection of low-dose streptozotocin (STZ, 25 mg/...

PURPOSE To characterize neuropeptide distribution in the ciliary ganglion of rhesus monkeys (Macaca mulatta). METHODS Cryostat tissue sections of fixed rhesus monkey ciliary, pterygopalatine, superior cervical, and trigeminal ganglia were incubated with antisera to neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), tyrosine hyd...

Abstract Background Vasospasm is an important etiological factor in the induction of acute myocardial infarction (AMI). PeriVascular Nerve Fibres (PVNF) and Adipose Tissue (PVAT) play role vasoregulation, although detailed information their heart missing AMI patients. In present study we have analysed PVNF PVAT deceased Methods Sections epicardial coronary arteries were obtained at autopsy from...

Stress and anxiety-related behaviors controlled by the basolateral amygdala (BLA) are regulated in vivo by neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF): NPY produces anxiolytic effects, whereas CRF produces anxiogenic effects. These opposing actions are likely mediated via regulation of excitatory output from the BLA to afferent targets. In these studies, we examined mechanism...

Mundinger, Thomas O., and Gerald J. Taborsky, Jr. Differential action of hepatic sympathetic neuropeptides: metabolic action of galanin, vascular action of NPY. Am. J. Physiol. Endocrinol. Metab. 278: E390–E397, 2000.—Activation of hepatic nerves increases both hepatic glucose production (HGP) and hepatic arterial vasoconstriction, the latter best described by a decrease of hepatic arterial con...