We are very concerned by the report entitled, “Liver Transplantation for Wilson’s Disease: A Single-Center Experience” which appeared in your journal (vol 5, pp 467-474, November 1999).1 Throughout the article, the authors infer, and in some places outright claim, that orthoptic liver transplantation (OLT) is an effective, and perhaps advantageous, way to treat the neurological symptoms of Wils...

increasing input from neurologists, especially with regard to the assessment of hypoxic brain damage and the neurological complications of critical illness, organ failure and sepsis. In contrast, dedicated neurological and neurosurgical intensive care units (ICUs) in neuroscience centres tend to deal with the management of primary diseases of the central and peripheral nervous system which may ...

Spontaneously occurring spinal epidural hematoma (SEH) is a relatively rare disease. It is frequently observed in cervicothoracic and thoracolumbar regions. They require emergency surgical intervention as they may lead to serious and permanent neurological damage. On the other hand, rare cases with mild neurological findings, which resolve without surgical intervention have also been reported i...

Objective. To report the irreversible severe neurological symptoms following the hyponatremic hypertensive syndrome (HHS) in an infant after umbilical arterial catheterization. Design. Case report with review of the literature. Setting. Neonatal intensive care unit at a tertiary care children's hospital. Patient. A three-week-old preterm infant. Conclusions. In evaluating a neonate with hyponat...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

We evaluated 56 patients for neurological deficit after enucleation of a histopathologically confirmed schwannoma of the upper limb. Immediately after the operation, 41 patients (73.2%) had developed a new neurological deficit: ten of these had a major deficit such as severe motor or sensory loss, or intolerable neuropathic pain. The mean tumour size had been significantly larger in patients wi...

Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders followin...

BACKGROUND AND PURPOSE Microplasmin (microPli), a derivative of plasmin lacking the 5 "kringle" domains, was studied in a rat thrombotic stroke model with MRI monitoring. METHODS Brain ischemia was induced by middle cerebral artery (MCA) occlusion with photochemically induced thrombosis. Brain tissue damage was assessed at 1 hour and 24 hours after MCA occlusion by MRI and 2,3,5-triphenyl tet...

Despite of the huge socio-economic burden, stroke still represents an unmet therapeutic need. Researchers failed to reproduce preclinical efficacy in subsequent clinical development. To bridge this translation failure, the Stroke Therapy Academic Industry Round Table (STAIR) has suggested a rigorous, robust, and detailed preclinical evaluation in at least 2 species and multiple cerebral ischemi...

Plant toxins are the chemical defenses of plants against herbivory. Grasses have relatively few intrinsic toxins, relying more on growth habit to survive defoliation and endophytic fungal toxins as chemical defenses. Forage grasses that contain intrinsic toxins include Phalaris spp. (tryptamine and carboline alkaloids), sorghums (cyanogenic glycosides), and tropical grasses containing oxalates ...