multiple sclerosis (ms) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. the temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...

A 53-year-old man with Behçet disease was treated with conventional cyclosporin A (CyA), because of refractory bilateral uveitis. Immediately following the conversion from conventional CyA to a microemulsion formulation, he presented with neurological complications. The neurological findings, pleocytosis of the cerebrospinal fluid (CSF) and brainstem lesions revealed by brain magnetic resonance...

neuroplasticity is the brain's ability to reorganize itself by forming new neural connections throughout life. neuroplasticity allows the neurons in the brain to compensate injury and disease and to adjust their activities in response to new situations or to changes in their environment. at the other side, it is now well established that neuronal function is strongly influenced by both cen...

Objectives: Brainstem is the most frequently affected neural substrate in neurological involvement due to Behçet’s disease (neuro-Behçet). The demonstration of brainstem involvement in Behçet’s disease (BD) is important in the management of this disorder. The evaluation of some brainstem reflexes (blink reflex and exteroceptive suppression of masseter) and brainstem auditory evoked potentials (...

Multiple Sclerosis (MS) is a complex disease resulting from the occurrence of intermingled episodes of neuro-inflammation and degeneration. The temporal and spatial patterns in which these events occur are not well understood as well as the molecular substrates underlying it. Myelin loss and gain, as well as axonal damage are considered crucial events influencing the course of the disease but t...

Pathologic hyperpermeability exists in the spectrum of disease states, including neuro-ischemic, neuro-inflammatory and neuro-oncological. To-date the characterization of disease pathology with T1-weighted quantitative dynamic contrast-enhanced magnetic resonance imaging has relied on the study of modeled microvascular parameters such as diseased tissue transvascular flow rates of small molecul...

The nucleoprotein (N) of Borna disease virus (BDV) is the major target of the disease-inducing antiviral CD8 T-cell response in the central nervous system of mice. We established two transgenic mouse lines which express BDV-N in either neurons (Neuro-N) or astrocytes (Astro-N). Despite strong transgene expression, neurological disease or gross behavioral abnormalities were not observed in these...

Neuroplasticity is the brain's ability to reorganize itself by forming new neural connections throughout life. Neuroplasticity allows the neurons in the brain to compensate injury and disease and to adjust their activities in response to new situations or to changes in their environment. At the other side, it is now well established that neuronal function is strongly influenced by both central ...