Transformed stem cells have been isolated from some human cancers. We report that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells. Similar, yet not identical, to their normal neural stem cell counterpart, these precursors emerge as unipotent (astroglial) in vivo and multipotent (...

Representing a renewable source for cell replacement, neural stem cells have received substantial attention in recent years. The neurosphere assay represents a method to detect the presence of neural stem cells, however owing to a deficiency of specific and definitive markers to identify them, their quantification and the rate they expand is still indefinite. Here we propose a mathematical inte...

We have characterized a strain of double transgenic mice with simian virus 40 large tumor antigen and prokaryotic lacZ under the control of the myelin basic protein promoter that develops spindle-cell sarcomas and osteogenic sarcomas at 5-7 months of age. Although poorly differentiated, the spindle-cell sarcomas were characterized as malignant Schwannomas based on their neural association, the ...

This study attempted to accurately segment the masses and distinguish malignant from benign tumors. The masses were segmented using a technique that combines pixel aggregation with likelihood analysis. We found that the segmentation method can delineate the tumor body as well as tumor peripheral regions covering typical mass boundaries and some spiculation patterns. We have developed a multiple...

objectives this study aimed at reviewing the current literature on the diagnosis, staging, and different treatment strategies for wilms’ tumor with either ureteral or intravascular extension. evidence acquisition in this article, we reviewed the current literature about staging, diagnosis, and management strategies for wt, through a randomized clinical trial, which focused on this matter. the m...

PURPOSE To determine the impact of radiation on neural stem cells and examine the feasibility of neural stem cell sparing using volumetric modulated arc therapy (VMAT) for whole brain irradiation. METHODS Murine neural stem cells were harvested from the sub-ventricular zone (SVZ), cultured and assessed for radio-sensitivity and differentiation potential in response to radiation (0-6Gy). Clono...

calcifying fibrous tumor (cft) is a rare mesenchymal tumor, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. cft of the tubular gastrointestinal tract is very rare with less than 20 cases of gastric cfts reported in english literature. this benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell tumors particularl...

purpose : to review periocular dermoid cysts to determine distribution of demographic factors, and tumor location methods : in this retrospective, observational case series in a tertiary-care hospital, we reviewed all cases of histopathologically verified periocular dermoid cysts at our institution between 2003 and 2011. the study endpoints included: age, gender, and tumor location. results : t...

In this research paper, a new modified approach is proposed for brain tumor classification as well feature extraction from Magnetic Resonance Imaging (MRI) after pre-processing of the images. The discrete wavelet transformation (DWT) technique used MRI images and Artificial Neural Network (ANN) type according to extracted features. Mean, Standard deviation, Variance, Entropy, Skewness, Homogene...