To study changes of Ryk expression in dorsal root ganglia (DRG) after peripheral nerve injury, we set up an animal model of unilateral sciatic nerve lesioned rats. Changes of Ryk protein expression in DRG neurons after unilateral sciatic nerve injury were investigated by immunostaining. Changes of Ryk mRNA were also tested by semi-quantitative PCR concurrently. We found, both at the level of pr...

PURPOSE Intracortical microinjection of fluorocitrate, a reversible inhibitor of glial tricarboxylic acid (TCA), results in impaired glial metabolism and epileptic seizures. To determine the potential contribution of epileptic activities to the metabolic properties of fluorocitrate, we investigated the seizure-inducing property of fluorocitrate at different doses. METHODS Twenty-seven male Sp...

Erythropoietin (EPO) ameliorates inflammation-induced injury in cerebral white matter (WM). However, effects of inflammation on the cerebellum and neuroprotective effects of EPO are unknown. Our aims were to determine: (i) whether lipopolysaccharide (LPS)-induced intrauterine inflammation causes injury to, and/or impairs development of the cerebellum; and (ii) whether recombinant human EPO (rhE...

Objective(s):This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on pyramidal neurons of hippocampus in 18 and 32 day mice offspring. Materials and Methods: Thirty female mice were randomly allocated into cases and controls. In case group, animals received morphinesulfate 10 mg/kg.body weight intraperitoneally during 7 days bef...

BACKGROUND Latest studies show that low-energy extracorporeal shock wave therapy (ESWT) can upregulate levels of vascular endothelial growth factor (VEGF). VEGF can ease nervous tissue harm after spinal cord injury (SCI). This study aims to explore whether low-energy ESWT can promote expression of VEGF, protect nervous tissue after SCI, and improve motor function. METHODS Ninety adult female ...

Zusammenfassung Freiwilliges Engagement ist eine zentrale Form gesellschaftlicher Teilhabe und bildet einen wichtigen Erfahrungsraum für lebenslanges Lernen. Welche Rolle freiwilliges als potenzieller Lernraum die Bewältigung kritischer Lebensereignisse von Ehrenamtlichen spielt, jedoch bislang nicht untersucht. Eine solche Betrachtung könnte dazu beitragen, Genese weitgehend isoliert untersuch...

Wir berichten über den Einbau klassischer Teerfarben (Michlers Keton, Methylen Blau, Rhodamin B und Kristallviolett) in selbstassemblierte Strukturen der Formel [Pd2L4]. Die Chromophore wurden unter Verwendung von Piperazin-Linkern bis-monodentate Liganden integriert. Dies erlaubt die Erhaltung für intensive Farbgebung verantwortlichen auxochromen Dialkylamin-Funktionen. mit Pyridin-Donoren bil...

Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks of age to examine the beneficial effects of combined JSQW and treadmill therapy...

Brain tumor patients routinely undergo cranial radiotherapy, and while beneficial, this treatment often results in debilitating cognitive dysfunction. This serious and unresolved problem has at present, no clinical recourse, and has driven our efforts to more clearly define the consequences of different brain irradiation paradigms on specific indices of cognitive performance and on the underlyi...