The centrality-lethality rule, which notes that high-degree nodes in a protein interaction network tend to correspond to proteins that are essential, suggests that the topological prominence of a protein in a protein interaction network may be a good predictor of its biological importance. Even though the correlation between degree and essentiality was confirmed by many independent studies, the...

Schizophrenia is postulated to be the prototypical dysconnection disorder, in which hallucinations are the core symptom. Due to high heterogeneity in methodology across studies and the clinical phenotype, it remains unclear whether the structural brain dysconnection is global or focal and if clinical symptoms result from this dysconnection. In the present work, we attempt to clarify this issue ...

Network models 8 Graph and network definitions . . . . . . . . . . . . . . . . . . 9 Data sources and databases . . . . . . . . . . . . . . . . . . 11 Random graphs . . . . . . . . . . . . . . . . . . . . . . . . . 13 Small World networks . . . . . . . . . . . . . . . . . . . . . . 15 Change in network research . . . . . . . . . . . . . . . . . . . 17 Scale-free networks . . . . . . . . . . . ....

One major task in the post-genome era is to reconstruct proteomic and genomic interacting networks using high-throughput experiment data. To identify essential nodes/hubs in these interactomes is a way to decipher the critical keys inside biochemical pathways or complex networks. These essential nodes/hubs may serve as potential drug-targets for developing novel therapy of human diseases, such ...

Biological networks often show a scale-free topology with node degree following a power-law distribution. Lethal genes tend to form functional hubs, whereas non-lethal disease genes are located at the periphery. Uni-dimensional analyses, however, are flawed. We created and investigated two distinct scale-free networks; a protein-protein interaction (PPI) and a perturbation sensitivity network (...

Abstrad: The design of an optical packet switched network to transport both data and voice, focussing on an IP client layer, is the subject of DAVID (Data And Voice Integration over DWDM), a research project fi.mded by the European Community. The network is composed of a metropolitan part, where optical rings are connected through devices denoted as Hubs. Those Hubs also provide the connection ...

Evaluation of trade-offs between dynamical characteristics and architecture design on large-scale networks is demanded for engineering solutions. We study dynamical characteristics of complex networks through both packet traffic simulation and theoretical network analysis to explore highperformance NoC (network-on-chip) architectures. To achieve efficient communication with hundreds of function...

Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of the network change pattern in T2DM patients. Thi...

Plant-animal mutualistic networks are characterized by highly heterogeneous degree distributions. The majority of species interact with few partner species, while a small number are highly connected to form network hubs that are proposed to play an important role in community stability. It has not been investigated, however, if or how the degree distributions vary among types of mutualisms or c...

Across species and tissues and especially in the mammalian brain, production of gene isoforms is widespread. While gene expression coordination has been previously described as a scale-free coexpression network, the properties of transcriptome-wide isoform production coordination have been less studied. Here we evaluate the system-level properties of cosplicing in mouse, macaque, and human brai...