BACKGROUND For peripheral nerve regeneration, recent attentions have been paid to the nerve conduits made by tissue-engineering technique. Three major elements of tissue-engineering are cells, molecules, and scaffolds. METHODS In this study, the attachments of nerve cells, including Schwann cells, on the nerve conduit and the effects of both growth factor and adhesion molecule on these attach...

Semaphorins constitute a diverse family of widely expressed transmembrane, diffusible, and GPI-linked proteins with versatile physiologic functions in orchestrating nerve system development, immune homeostasis, angiogenesis, cell metabolism. Accumulating evidence highlights semaphorins as essential regulators tumorigenesis by coordinating the cell-cell communications tumor microenvironment. Sem...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

the overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. it would be of particular importance to interrupt the progress of events h...

multiple sclerosis (ms) is a chronic inflammatory disease characterized by central nervous system (cns) lesions that can lead to severe physical or cognitive disability as well as neurological defects. although the etiology and pathogenesis of ms remains unclear, the present documents illustrate that the cause of ms is multifactorial and include genetic predisposition together with environmenta...