Radiation nephritis has not had wide attention in the medical literature. Maniy physicians have erroneously considered the kidney to be resistant to the effects of irradiation. This illusion is partly due to the fact that the clinical signs of renal impairment are often subtle and therefore overlooked, or are mistakenly attributed to the primary condition for which radiotherapy was given. Furth...

A study was carried out of 274 children in Scotland aged 0 to 13 years recorded as having had acute nephritis over a four-year period (1976-79). The medical records for 223 of the patients were examined and 79 cases of poststreptococcal nephritis were identified, giving an estimated incidence of 2.1 episodes per 100,000 children per year. Using a number of assumptions, the authors sought the an...

Uttley, W. S., Maxwell, H., and Cash, J. D. (1974). Archives of Disease in Childhood, 49, 137. Fibrin/fibrinogen degradation products in children with renal disease. Fibrin/fibrinogen degradation products (FDP) were measured in the serum and urine of children with various forms of renal disease. Serum FDP was raised both with nephrosis and with active proliferative nephritis. Urine FDP was rare...

Immature renal dendritic cells (DCs) are protective early in murine crescentic GN, but the mechanisms underlying this protection are unknown. Here, depletion of DCs reduced the recruitment of invariant natural killer T (iNKT) cells, which attenuate GN, into the kidney in the early stage of experimental crescentic GN. More than 90% of renal iNKT cells expressed the chemokine receptor CXCR6, and ...

Kidneys are the most vital organs of the dogs which helps to excrete the metabolic waste products from the body and to maintain the electrolyte, water and other solute balances. These kidneys time to time suffer from the bacterial infections causing bacterial nephritis due to the infections of Escherichia coli, Staphylococcus spp., Streptococcus spp., Enterococcus, Proteus spp., Klebsiella spp....

Abnormalities of prostanoid metabolism, which may affect renal function, were studied in lupus nephritis. The subjects were 31 patients with lupus nephritis, ten with non-renal SLE, and four with renal, non-SLE collagen disease. Urinary levels of various prostanoids, thromboxane B2(TXB2), 11-dehydro-TXB2, 6-keto-PGF1 alpha,2,3-dinor-6-keto-PGF1 alpha and PGE2, and plasma level of 11-dehydro-TXB...

BACKGROUND IgA nephropathy (IgAN) and nephritis in Systemic Lupus Erythematosus (SLE) are two common forms of glomerulonephritis in which genetic findings are of importance for disease development. We have recently reported an association of IgAN with variants of TGFB1. In several autoimmune diseases, particularly in SLE, IRF5, STAT4 genes and TRAF1-C5 locus have been shown to be important cand...

INTRODUCTION Pediatric systemic lupus erythematosus (pSLE) patients often initially present with more active and severe disease than adults, including a higher frequency of lupus nephritis. Specific autoantibodies, including anti-C1q, anti-DNA and anti-alpha-actinin, have been associated with kidney involvement in SLE, and DNA antibodies are capable of initiating early-stage lupus nephritis in ...

Lupus glomerulonephritis is a common and serious complication of systemic lupus erythematosus (SLE) affecting up to 50% of lupus patients. Recurrent lupus nephritis is rare, complicating as low as 1% of the lupus transplant population according to some authors. However, it may be underreported with more realistic recurrent rates oscillating from 2.8 to 8.7%. We report the case of a patient with...

Most patients with SLE develop kidney disease related to this systemic underlying disease process. Lupus nephritis is an important cause of morbidity and even mortality in patients with systemic lupus erythematosus. Lupus nephritis has diverse morphologic manifestations with varying clinical presentations and consequences. The pathogeneses involve immune complexes, which can deposit anywhere in...