Modified synthetic N-POMC(1-28) without disulfide bridges has been shown to act as an adrenal mitogen. Cyclins and their inhibitors are the major cell cycle controls, but in the adrenal cortex the effect of ACTH and N-POMC on the expression of these proteins remains unclear. In this work, we evaluate the effect of different synthetic N-POMC peptides on the S-phase of the cell cycle. In addition...

In Lyon hypertensive (LH) rats, a model of low-renin genetic hypertension, we investigated adrenal sensitivity to angiotensin II in terms of angiotensin II receptor (AT1 and AT2 receptors) regulation, morphological changes, and aldosterone and corticosterone secretion. Twelve-week-old LH rats, compared with normotensive LN and LL rats, were either untreated or treated for 4 weeks with AT1 recep...

We examined further the ffects of angiotensin-11 and K+ on phospholipid metabolism in the adrenal zona glomerulosa. In adrenal zona glomerulosa cell preparations, physiological and supraphysiological concentrations of angiotensin-I1 (10"2-10-4 M) and K+ (0-16 m ~ ) elicited doseand time-dependent increases in aldosterone production and (32P)phosphate incorporation into chromatographically purif...

This study aimed to elucidate the role of the AT(2) receptor (AT(2)R), which is expressed and upregulated in the adrenal zona glomerulosa (ZG) under conditions of increased aldosterone production. We developed a novel transgenic rat (TGR; TGRCXmAT(2)R) that overexpresses the AT(2)R in the adrenal gland, heart, kidney, brain, skeletal muscle, testes, lung, spleen, aorta, and vein. As a consequen...

In adrenal glomerulosa cells, the stimulation of aldosterone biosynthesis by angiotensin II (Ang II) involves the activation of a capacitative Ca(2+) influx through calcium release-activated calcium (CRAC) channels. In various mammalian cell systems, it has been shown that CRAC channel activation and Ca(2+) entry require tyrosine kinase activity. We have therefore examined in this work whether ...

The neuroendocrine system regulates several organic functions such as reproduction, metabolism and adaptation to the environment. This system shows seasonal changes linked to the environment. The experimental model used in the present study was Lagostomus maximus maximus (viscacha). The reproduction of males of this species is photoperiod dependent. Twenty-four adult male viscachas were capture...

The article provides an information about the finds of six adventitious plant species in Sverdlovsk Region, two them are new to flora region (Hesperis pycnotricha Borbás et Degen., Nepeta sibirica L.). Four (Lotus corniculatus L., Silene dichotoma Ehrh., Urtica cannabina Vicia amoena Fisch.) were previously known from 1–2 localities Region and rare not only region, but also adjacent territories...