Sugammadex is a novel neuromuscular blockade (NB) reversal agent that has demonstrated faster and more predictable than acetylcholinesterase inhibitors such as neostigmine. Despite published literature on cost/benefit utilization, financial concerns of broad implementations sugammadex usage have been noted. To understand potential demographic differences between neostigmine use, we examined bas...

Abstract Background This study aimed to compare the duration of postoperative analgesia using intraperitoneal bupivacaine plus neostigmine or alone. In this randomized controlled trial, we included 56 adult patients scheduled for elective laparoscopic cholecystectomy operation. Patients were randomly allocated into two groups group (B group) who received 50 ml 0.25% alone and bupivacaine-neosti...

We have compared the antagonism of neuromuscular block produced by pipecuronium with pancuronium in 80 anaesthetized surgical patients using mechanomyography and electromyography. Pancuronium 0.1 mg kg-1 or pipecuronium 0.07 mg kg-1 was given after induction of anaesthesia and neuromuscular block was adjusted to 75% twitch depression at the time of antagonism. The following regimens were used: ...

In this experiment, 98 multiparous Yorkshire sows blocked on farrowing date were randomly assigned to four treatments in a 2 x 2 factorial arrangement. Oxygen inhalation (6 L/min) by the sow was tested in an effort to reduce stillbirth rate and improve pig viability. This study also tested the effect of increasing uterine contractions using neostigmine (5 mg) to determine whether simultaneous a...

Microinjections of the cholinergic receptor agonist nicotine and the cholinesterase inhibitor neostigmine were made into the ventral tegmental area (VTA) of urethane-anesthetized rats, and dopamine (DA) efflux in the nucleus accumbens was measured using in vivo chronoamperometry. Dose-dependent increases in the chronoamperometric signals corresponding to increased DA efflux were observed in the...

The study was designed to test the hypothesis that the inhibition of acetylcholinesterase (AChE) activity at the periphery by Neostigmine (0.5 mg/animal) will be sufficient to prevent inflammatory dependent suppression of the gonadotropin-releasing hormone (GnRH)/luteinising hormone (LH) secretion in ewes in the follicular phase of the estrous cycle, and this effect will be comparable with the ...