UNLABELLED Respiratory syncytial virus (RSV) infection is the number one cause of bronchiolitis in infants, yet no vaccines are available because of a lack of knowledge of the infant immune system. Using a neonatal mouse model, we previously revealed that mice initially infected with RSV as neonates develop Th2-biased immunopathophysiologies during reinfection, and we demonstrated a role for en...

BACKGROUND Polymicrobial infections in adults and children are associated with increase in mortality, duration of intensive care and healthcare costs. Very few studies have characterized polymicrobial bloodstream infections in the neonatal unit. Considerable variation has been reported in incidence of polymicrobial infections and associated clinical outcomes. We characterized the risk factors a...

Yeung, C. Y., and Tam, A. S. Y. (1972). Archives of Disease in Childhood, 47, 735. Gastric aspirate findings in neonatal pneumonia. A study on the gastric aspirate findings in infants with features of neonatal pneumonia and in healthy controls is presented. Definite pneumonia was associated with thickly mucoid gastric fluid containing a high proportion of polymorphonuclear leucocytes. Healthy i...

Syphilis in pregnancy can cause considerable fetal and neonatal morbidity and mortality. It is endemic in the developing world but it is now resurgent in the developed world. Maternal syphilis can result in fetal infection leading to fetal and neonatal harm. Mid-trimester miscarriages, stillbirths, low birth weight, prematurity, congenital syphilis and neonatal deaths are all the results of syp...

A 30-year-old pregnant woman had skin lesions at 38 weeks of gestation. She was diagnosed as primary varicella zoster infection. Her clinical symptoms were high fever and generalized vesicles eruption. No serious maternal complication was found. The patient delivered a male baby 4 days after she developed skin lesions. The neonatal blood IgM against varicella zoster was negative. The baby was g...

According to Professor Anne Greenough, Professor of Neonatology and Clinical Respiratory Physiology at the King's College London (London, UK), Paediatric Virology is indeed a rapidly increasing educational challenge. Professor Greenough, who in 1992 wrote her book on congenital, perinatal and neonatal infections, believes that during the past 3 decades, paediatric health professionals are becom...

Intra-uterine and oral temperatures were recorded in 23 patients with fetal tachycardia during labour, as well as in 22 patients without fetal tachycardia. In the tachycardia group, the mean intra-uterine temperature was 38,83 degrees C, against 37,44 degrees C in the control group. The oral temperatures were 38,05 degrees C and 33,98 degrees C respectively. Furthermore, a high incidence of neo...

A 12-year retrospective study to elucidate the incidence of "fifth day fits" including 127 infants with neonatal convulsions was carried out in the Randers area of Denmark. The incidence of neonatal convulsions was 8.3/1,000 live-born infants. The etiology in 74 cases of latent and 53 cases of convulsive seizures was asphyxia (38%), intracranial hemorrhage (17%), hypoglycaemia (9%), hypocalcaem...

BACKGROUND HIV-infected women, particularly those with advanced disease, may have higher rates of pregnancy loss (miscarriage and stillbirth) and neonatal mortality than uninfected women. Here we examine risk factors for these adverse pregnancy outcomes in a cohort of HIV-infected women in Zambia considering the impact of infant HIV status. METHODS A total of 1229 HIV-infected pregnant women ...

Introduction. To investigate whether maternal oral flora might be involved in intrauterine infection and subsequent stillbirth or neonatal death and could therefore be detected in fetal and neonatal postmortem bacterial cultures. Methods. This retrospective study of postmortem examinations from 1/1/2000 to 12/31/2010 was searched for bacterial cultures positive for common oral flora from heart ...