Neonatal sepsis is an important cause of morbidity and mortality as a result of multiple organ system failure, particularly in neonates requiring total parenteral nutrition. Suitable therapies and support are needed both to prevent sepsis and to prevent multiple organ failure. After bacterial infection, pro-inflammatory cytokines trigger the antimicrobial activity of macrophages and neutrophils...

BACKGROUND Induction of hypothermia (a 4 °C decrease from baseline) improves outcomes in adult cardiac arrest and neonatal hypoxic ischemic encephalopathy, and may benefit other conditions as well. Methods used to implement or prevent hypothermia typically require skin contact with blankets or pads or intravascular access with catheter devices. The study was to evaluate the potential to induce ...

The focus of this review is to collate the literature on the phenomenon of impaired thermal adaptation after hypoxic ischaemic (HI) delivery often culminating in hypothermia. This phenomenon appears different in severity and duration to a spontaneous postnatal fall in temperature observed after normal delivery. The original observation and contemporary descriptions of the temperature response t...

This analysis is a case-series to document the outcome of term newborns with hypoxic ischaemic encephalopathy (HIE), enrolled into total body hypothermia therapy, in a tertiary neonatal unit in Malaysia. The method used to achieve total body hypothermia is a novel method using just environmental temperature, without the need of expensive equipment. A total of 17 babies were eligible to be inclu...

Surkov. Temperature and neonatal hypoxic-ischemic encefalopathy 1 Key points Therapeutic hypothermia or targeted temperature management has been shown to improve outcome after perinatal asphyxia in large clinical trials. Controlled cooling has become the standard of care for newborns with hypoxicischemic encephalopathy but preference of its method still remains controversial. The efficacy and s...

An assessment of the incubators in use at the Kathmandu Maternity Hospital neonatal unit was undertaken; this was followed by a prospective survey of neonatal temperatures on the unit. In the incubator assessment 11 studies were carried out in five incubators. Three of the thermostats in the five incubators did not work at all and those in the other two incubators were more than 3 degrees C ina...

Background: The clinical use of amplitude integrated electroencephalogram (aEEG) in the neonatal intensive care unit has largely increased. This method has been reported to have a very good predictive value for neurodevelopmental outcome in term neonates after perinatal asphyxia. Aim: The aim of this study was to assess the recovery of aEEG patterns during hypothermic treatment in full term asp...

This discussion offers guidelines for the management of sick neonatal foals during initial evaluation on the farm and prior to referral to a secondary care facility. Essential history regarding the pregnancy and delivery, placental examination, highlights of neonatal examination, and selected laboratory tests are discussed with regard to early diagnosis of the foal’s primary problem(s). The mos...

This study compared mothers’ and newborns’ temperatures (T) when the WHO recommended skin-to-skin contact (SSC) was practiced during cesarean section under regional anesthesia. 139 neonates were randomized to be left in their mothers’ arms warmed by a forced air warmer (SSC-FAW) or put in an incubator. Maternal and newborn rectal T was recorded immediately after birth, at 5, 10 and 15 minute in...