BACKGROUND The objective of this study was to compare neonatal outcomes in women with gestational diabetes mellitus (GDM) treated with either metformin or insulin. MATERIALS AND METHODS A randomized clinical trial carried out on year 2011 on 109 women with GDM who did not adequately control by dietary measures. They received metformin 500 mg once or twice daily or insulin 0.2 IU/kg/day initia...

BACKGROUND Exposure to antidepressants during the third trimester of pregnancy has been associated with an increased risk for adverse birth outcomes, including preterm birth, respiratory distress, and hypoglycemia. OBJECTIVE To investigate neonatal outcomes in 997 infants (987 mothers) after maternal use of antidepressants based on prospectively recorded information in antenatal care document...

Background: The rate of Cesarean section is increasing which may be due to maternal and neonatal issues. Preterm Cesarean (at 38-39 weeks) has several morbidities and leads to maternal problems. The goal of this study was to compare neonatal and maternal complications following the performance of the Cesarean section after 38 weeks.Methods: This cross-sectional study evaluated 1010 subjec...

OBJECTIVES Neonatal hypoglycaemia is a potential cause of neonatal morbidity, and on rare but tragic occasions causes long-term neurodevelopmental harm with consequent emotional and practical costs for the family. The organisational cost to the NHS includes the cost of successful litigation claims. The purpose of the review was to identify themes that could alert clinicians to common pitfalls a...

Diazoxide is a benzothiadiazine derivative, chemically closely related to thiazide diuretics but lacking diuretic activity. Fajans et al (1968) have recorded this agent's ability of supress insulin release from normal and abnormal islet cell tissue. This property was exploited in the treatment of our patient, a 16 week-old infant with severe, prolonged symtomatic hypoglycaemia. Unfortunate adve...

Introduction It is well known that pregnancy is associated with an increase in plasma cortisol and that especially in the third trimester the values attained resemble a state of adrenocortical hyperfunction (Kopelman & Levitz, 1970). It has also been shown that the concentration of cortisol in cord blood reflects the maternal state although it is less than the corresponding maternal values and ...

Low blood sugar concentrations are common in infants, and concentrations which in the adult would be considered pathologically low may be physiological in the newborn in whom hypoglycaemia is not necessarily associated with symptoms (Ketteringham and Austin, 1938; McKittrick, 1940; Hanley and Horn, 1943; Norval, Kennedy, and Berkson, 1949; Wachter, 1949; Pedersen, 1952; Desmond, 1953; Lowrey, G...