Cholestasis in early infancy represents a diagnostic dilemma and most of these infants suffer either from extrahepatic biliary atresia or idiopathic neonatal hepatitis. Differentiation between the two conditions may be extremely difficult both clinically and biochemically, and a diagnostic liver biopsy is usually required. We report on a Sudanese infant who presented at the age of 4 weeks with ...

Neonatal jaundice (NNJ) is the commonest problem in Hong Kong neonates.1 It is most likely to be unconjugated hyperbilirubinemia. Dramatic change was observed in last three decades with a sharp drop in incidence of kernicterus. This improvement was achieved through the concerted effort of the communi ty, neonato log ists, communi ty medical practitioners, health nurses. Significant effort was p...

Objectives  We report on a patient suffering from intractable itching secondary to intrahepatic cholestasis of pregnancy (ICP) unresponsive to conventional medical therapies. She was started on a regimen of therapeutic plasma exchange (TPE), which is often efficacious in relieving patient's itching from all causes of cholestasis, including ICP. Methods  We performed a retrospective review of a ...