Schizophrenia is apparently less common in traditional than in nontraditional societies, and the course of illness in these cultural settings may also be more benign. Viral, political, economic, social labeling, and other explanations have been offered over the years for these differences. In contrast to those ideas that suggest the presence of a schizophrenogenic stress in urbanized, Westerniz...

Positive selection is usually considered in the context of a higher rate of substitutions in non-synonymous as compared to synonymous sites in complete coding sequences of genes or individual positions. We show that genes conserved in eukaryota, coelomata, and bilateria, that is, proteins that arose earlier in evolution as compared to mammalia specific genes evolve slowly and are subjected to n...

The (randomized) real-valued negative selection algorithm is an anomaly detection approach, inspired by the negative selection immune system principle. The algorithm was proposed to overcome scaling problems inherent in the hamming shape-space negative selection algorithm. In this paper, we investigate termination behavior of the realvalued negative selection algorithm with variable-sized detec...

We use matched employee-employer records from the teacher labor market to explore the effects of late teacher hiring on student achievement. Hiring teachers after the school year starts reduces student achievement by 0.042SD in mathematics and 0.026SD in reading. This reflects, in part, a temporary disruption effect in the first year. In mathematics, but not in reading, late-hired teachers rema...

We have developed a rapid negative selection method to enrich rare mononuclear cells from human tissues. Unwanted and antibody-tethered cells are selectively depleted during a Ficoll separation step, and there is no need for magnetic-based reagents and equipment. The new method is fast, customizable, inexpensive, remarkably efficient, and easy to perform, and per sample the overall cost is less...

Negative selection against protein instability is a central influence on evolution of proteins. Protein stability is maintained over evolution despite changes in underlying sequences. An empirical all-site stability-based model of evolution was developed to focus on the selection of residues arising from their contributions to protein stability. In this model, site rates could vary. A structure...

The identity of the self determinants involved in the selection of the T cell repertoire has been a matter of considerable interest. In addition to the apparent critical role of MHC gene products, accumulated experimental results indicate the importance of non-MHC gene products in T cell repertoire selection. In particular, murine Mlsa and Mlsc determinants have been shown to be highly stimulat...

Logistics outsourcing has been at the top of the management agenda during recent decades. The selection of the proper service supplier is the key to success in logistic outsourcing Firms could select the right supplier by applying appropriate methods and selection criteria. In this paper a new framework is proposed on the basis of weighted additive fuzzy programming approach and linear programm...

Mobile ad hoc networks (MANETs) are multi-hop wireless networks of mobile nodes constructed dynamically without the use of any fixed network infrastructure. Due to inherent characteristics of these networks, malicious nodes can easily disrupt the routing process. A traditional approach to detect such malicious network activities is to build a profile of the normal network traffic, and then iden...