BACKGROUND The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries. However, there are already clinical isolates of Gram-negative bacteria that are resistant to all available antibiotics, including polymyxins. METHODS We present a case series of patients with infections due to pathogens resistant to all antimi...

Concurrent infections are a common complication of viral respiratory infections. They pose diagnostic challenges due to an overlap similar symptoms, resistance treatment and extending length hospital stay. In this review we will extensively discuss the most concurrent in patients with coronavirus disease 2019 (COVID-19). A thorough literature search was conducted online databases such as PubMed...

BACKGROUND When hospital-acquired or ventilator-associated bacterial pneumonia (HABP/VABP) is caused by gram-positive and gram-negative pathogens or both (mixed infections), the adequacy of gram-negative coverage (GNC) can confound the assessment of a gram-positive agent under study. This analysis examines the influence of gram-negative infections and the adequacy of GNC on clinical efficacy an...

The pathogenic nature of many infectious bacteria is enhanced by their ability to form surface-associated, protected communities known as "biofilms." Due to various factors, bacteria in biofilm communities display significantly greater resistance to traditional antimicrobial therapies than their planktonic brethren. This resistance complicates many common bacterial infections, resulting in recu...

The introduction of newly devised wound dressing has been a major breakthrough in the management of wounds or infections. The aims of this paper are to isolate and identify bacterial species causing burn wound infections from a University-related Iranian hospital as well as determination of the antimicrobial susceptibility of the isolated microorganisms to newly devised nanocomposite materials ...

Chronic wound infections are typically polymicrobial; however, most in vivo studies have focused on monospecies infections. This project was designed to develop an in vivo, polymicrobial, biofilm-related, infected wound model in order to study multispecies biofilm dynamics and in relation to wound chronicity. Multispecies biofilms consisting of both Gram negative and Gram positive strains, as w...