Idiopathic inflammatory myopathies are autoimmune diseases characterized by symmetrical proximal muscle weakness. Our aim was to identify a correlation between VDR polymorphisms or haplotypes and myositis. We studied VDR-BsmI, VDR-ApaI, VDR-TaqI, and VDR-FokI polymorphisms and haplotypes in 89 Hungarian poly-/dermatomyositis patients (69 females) and 93 controls (52 females). We did not obtain ...

BACKGROUND Focal myositis is a rare benign inflammatory pseudotumor, presenting as a painful nodular mass within a muscle, and characterized by spontaneous resolution within weeks. PURPOSE To assess the clinical and imaging findings of focal nodular myositis simulating a neoplasm at clinical examination, with no history of trauma. MATERIAL AND METHODS This study describes the locations and ...

1. Lischner M, Prokocimer M, Zolberg A, Shaklai M. Autoimmunity in chronic lymphocytic leukaemia. Postgrad Med J 1988;64:590–2. 2. Salvi A, Balestrier GP, Spandrio S, Franceschini R, Maroccolo M, Giustina G. Polymyositis associated with chronic lymphocytic leukemia. Clin Exp Rheumatol 1991;9:209–10. 3. Cherin P, Piette JC, Herson S, Raguin G, Godeau P. Polymyositis associated with chronic lymph...

Idiopathic inflammatory myositis (IIM) is a group of rare connective tissue diseases (CTDs) characterised by muscular and extramuscular signs, in which lung involvement is a challenging issue. Interstitial lung disease (ILD) is the hallmark of pulmonary involvement in IIM, and causes morbidity and mortality, resulting in an estimated excess mortality of 50% in some series. Except for inclusion ...

UNLABELLED Inclusion body myositis is a rare idiopathic inflammatory myopathy that produces extreme muscle weakness. Blood flow restricted resistance training has been shown to improve muscle strength and muscle hypertrophy in inclusion body myositis. OBJECTIVE The aim of this study was to evaluate the effects of a resistance training programme on the expression of genes related to myostatin ...

Autoantibodies occur in low frequencies among patients with myositis characterizing only distinct subsets of this disease. Most of these known antibodies are directed to enzymatically active complexes. The 20S proteasome represents an essential cytoplasmatic protein complex for intracellular nonlysosomal protein degradation, and is involved in major histocompatibility complex class I restricted...

Introduction Myositis is a general term used to define the inflammation of muscles. In the acute forms of myositis, this inflammation is caused by trauma, infection, certain drugs and even exercise. The chronic and sometimes progressive form of myositis is a rare condition that affects 10 in one million people each year. There has been considerable research into the pathological conditions of t...

Idiopathic inflammatory myopathies are systemic, chronic autoimmune diseases characterized by symmetrical, proximal muscle weakness. Homogeneous groups present with similar symptoms. The response to therapy and prognosis could be facilitated by myositis-specific autoantibodies, and in this way, give rise to immunoserological classification. The myositis-specific autoantibodies are directed agai...

UNLABELLED Methimazole is an anti-thyroid drug commonly used to treat hyperthyroidism and is a relatively safe medication. Several side effects have been reported and usually develop within 3 months of therapy. Well-known adverse reactions include agranulocytosis, hepatitis, skin eruptions, and musculoskeletal complaints such as myalgia, arthralgia, and arthritis. So far, myositis secondary to ...