نتایج جستجو برای: ncam

تعداد نتایج: 1011  

Journal: :Protein science : a publication of the Protein Society 2008
Arthur Kochoyan Flemming M Poulsen Vladimir Berezin Elisabeth Bock Vladislav V Kiselyov

The fibroblast growth factor receptor (FGFR) can be activated through direct interaction with the neural cell adhesion molecule (NCAM). The extracellular part of the FGFR consists of three immunoglobulin-like (Ig) modules, and that of the NCAM consists of five Ig and two fibronectin type III (F3) modules. NCAM-FGFR interactions are mediated by the third FGFR Ig module and the second NCAM F3 mod...

2011
Esther Castillo-Gómez Emilio Varea José Miguel Blasco-Ibáñez Carlos Crespo Juan Nacher

Decreased expression of dopamine D2 receptors (D2R), dysfunction of inhibitory neurotransmission and impairments in the structure and connectivity of neurons in the medial prefrontal cortex (mPFC) are involved in the pathogenesis of schizophrenia and major depression, but the relationship between these changes remains unclear. The polysialylated form of the neural cell adhesion molecule (PSA-NC...

Journal: :Neurobiology of learning and memory 2009
Reto Bisaz Lisa Conboy Carmen Sandi

Stress is known to be a potent modulator of brain function and cognition. While prolonged and/or excessive stress generally exerts negative effects on learning and memory processes, acute stress can have differential effects on memory function depending on a number of factors (such as stress duration, stress intensity, timing and the source of the stress, as well as the learning type under stud...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
V F Rafuse L Polo-Parada L T Landmesser

The role of neural cell adhesion molecule (NCAM) in the development and maturation of the neuromuscular junction (NMJ) was explored by characterizing structurally and functionally NMJs from postnatal day 11 (P11) to P30 +/+, +/-, and -/- NCAM null mutant mice. Differences in NCAM levels resulted in alterations in the size and shape of NMJs, with -/- NMJs being smaller. Additionally both the wit...

Journal: :Development 1993
I Valarché J P Tissier-Seta M R Hirsch S Martinez C Goridis J F Brunet

Transcriptional regulation of the gene encoding the cell adhesion receptor NCAM (neural cell adhesion molecule), a putative effector molecule of a variety of morphogenetic events, is likely to involve important regulators of morphogenesis. Here we identify two mouse homeodomain proteins that bind to an upstream regulatory element in the Ncam promoter: Cux, related to Drosophila cut and human CD...

2013
Jiho Jang Han-Soo Kim Joon Won Kang Hoon-Chul Kang

PURPOSE Cell transplantation of myelin-producing exogenous cells is being extensively explored as a means of remyelinating axons in X-linked adrenoleukodystrophy. We determined whether 3,3',5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in the polysialylated (PSA) form of neural cell adhesion molecule (NCAM)-positive cells and promotes cell proliferation and favors oligodendrocyte line...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Gaga Kochlamazashvili Oleg Senkov Sergei Grebenyuk Catrina Robinson Mei-Fang Xiao Katharina Stummeyer Rita Gerardy-Schahn Andreas K Engel Larry Feig Alexey Semyanov Vishnu Suppiramaniam Melitta Schachner Alexander Dityatev

The neural cell adhesion molecule (NCAM) is the predominant carrier of alpha2,8 polysialic acid (PSA) in the mammalian brain. Abnormalities in PSA and NCAM expression are associated with schizophrenia in humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in mice. Here, we show that PSA inhibits opening of recombinant NMDA receptors composed of GluN1/2B...

Journal: :Journal of neuropathology and experimental neurology 2001
G B Fox C Kjøller K J Murphy C M Regan

To investigate the role of polysialylated neural cell adhesion molecule (NCAM PSA)-mediated plasticity after injury, we examined the temporal and spatial expression of NCAM PSA immunoreactivity in the medial temporal lobe following global ischemia. Male Mongolian gerbils were subjected to bilateral common carotid artery occlusion for 5 min and killed at increasing times post-occlusion. The well...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
D T Theodosis R Bonhomme S Vitiello G Rougon D A Poulain

Polysialic acid (PSA) on the extracellular domain of the neural cell adhesion molecule (NCAM) reduces cell adhesion and is considered an important regulator of cell surface interactions. The hypothalamo-neurohypophysial system (HNS), whose glia, neurons, and synapses undergo striking, reversible morphological changes in response to physiological stimulation, expresses high levels of PSA-NCAM th...

Journal: :The international journal of neuropsychopharmacology 2010
Anne Albrecht Jorge Ricardo Bergado-Acosta Hans-Christian Pape Oliver Stork

Evidence suggests that the neural cell adhesion molecule (NCAM) is an important molecular constituent of adaptive and maladaptive circuit (re-)organization in the central nervous system. Here, we further investigate its putative involvement in amygdala and hippocampus functions during context fear memory formation. Using laser capture microdissection and quantitative RT-PCR, we show high NCAM m...

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