The antitumor drugs NB-506 and J-107088 are potent topoisomerase I inhibitors with an indolocarbazole structure. To clarify the factors involved in resistance to these drugs, we established two NB-506-resistant mouse fibroblast cell lines (LY/NR1 and LY/NR2), a human colon carcinoma cell line (HCT116/NR1), and a lung cancer cell line (PC13/NR1). These cell lines were highly resistant to NB-506 ...

Graphite is widely used in technology because of its unique properties. A drawback of graphite is its low heat resistance in oxidizing atmospheres. To increase its heat resistance, Nb-Hf protective coatings were synthesized. Electrodeposition of niobium coatings on graphite with subsequent precise surface alloying of niobium with hafnium was studied. Electrochemical synthesis of Nb-Hf coatings ...

A hexagonal oxynitride (Li(0.88)□(0.12))Nb(3.0)(O(0.13)N(0.87))(4) was synthesized through ammonia nitridation of LiNb(3)O(8). The structural analysis revealed that this oxynitride consists of alternate stacking of octahedral and prismatic layers with different Li/Nb ratios: significant amounts of Li and Nb atoms (Li/Nb = 43/57) coexist in the octahedral layer, while the prismatic site is prefe...

a low carbon al-killed ti-added steel was produced in mobarakeh steel complex in iran. mechanical properties and microstructural characterizations of steel in the as-cast, hot-rolled, cold-rolled and annealed conditions are presented. dilatometery tests were carried out to measure the finishing and annealing temperatures of steel. it was found that the addition of small amounts of ti increased ...

Cast strips of 0.1mass% C steel with or without phosphorus addition have been characterized by electron back-scattering diffraction pattern (EBSP) measurements. Then the formation of globular ferrite structure was discussed. EBSP analysis combined with optical microscopy clearly showed that a globular grain was fitted to be an -ferrite grain. The EBSP analysis suggested that the retainedgrain g...

The Urban Heat Island (UHI) phenomenon prevalently concerns industrialized countries. It consists of a significant increase in temperatures, especially in industrialized and urbanized areas, in particular, during extreme warm periods like summer. This paper explores the climate variability of temperatures in two stations located in Matera city (Southern Italy), evaluating the increase in temper...

dissimilar metals friction welding of austenitic–martensitic stainless steels is commonly used in order to manufacture engine valves in the automobile industry. in this study, x53crmnnin219 (austenitic stainless steel) and x45crsi93 (martensitic stainless steel) valve steel rods were welded by friction welding process. the welded joint was then heat treated at 760 0c for 60 min. mechanical prop...