Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the crystal structures. The best compound, (S)-6-((1-(4-chlorophenyl)ethyl)amino)-1-cyclopentyl-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-day]pyrimidin-4-one...

today, environmental crisis and loss of natural resources are the principle causes of the creation of environmental management systems. the optimal management of natural resources requires the assessment and classification of ecological and environmental potentials. using this method, the abilities and restrictions of resources can be recognized, and their future trends can be predicted. nebka ...

This paper analyzes the initial filing and the subsequent renewal decisions of the international patent applicants. Specifically I use as data input a comprehensive patent documentation collected from the EUropean Patent Office (EPO) that was unprecedented in its level of disaggregation by various characteristics such as nationality of inventor, type of technology and designated country of pate...

Economic theory predicts that the current change in national wealth, broadly defined to include natural and human capital as well as produced capital (“genuine savings”), determines whether the present value of future changes in consumption is positive or negative. Theoretical research has focused on the effects of population growth on this relation, but no rigorous empirical investigation has ...

abstract this study investigates casual relationship between co2 emission and gross domestic product per capita in five different country groups, using cross- country data for the period 1960-2007. to achieve the purpose, the co- integration test and error correction models are applied. results confirm casual relationships between the two variables. a unilateral relationship between gdp and co2...

Recently, considerable emphasis has been placed on the problems arising out of cross-sectional dependence in panel unit root tests. This paper adopts the factor based cross-sectional dependence paradigm of Bai and Ng (2004) but suggests alternative factor extraction methods. Some theoretical results for these methods are provided. Further, a detailed Monte Carlo study of these methods for multi...

We study the updating of beliefs under ambiguity for invariant biseparable preferences. In particular, we show that a natural form of dynamic consistency characterizes the Bayesian updating of these beliefs. JEL classification: D81

in the present time, phenomenon like globalization, regionalism and economic integration are the basic issues which bring many positive consequences to the world economy. regionalism and economic integration are one of the ways that developing countries can adopt to collate the globalization process. to acknowledge their own abilities or, to settle the commercial and economic disputes in their ...

Ekonomide belirsizlik, dış ticaret ve döviz kuru gibi makro ekonomik değişkenler üzerinde etkili olabilmektedir. Küreselleşmenin ilerlemesi ekonomilerin karşılıklı bağımlılığının artmasıyla birlikte uluslararası ticaret, ekonomide yaşanan belirsizlik ortamından güçlü bir şekilde etkilenmektedir. Literatürde ekonomi politika belirsizliğinin üzerindeki etkilerine ilişkin tam olarak görüş birliği ...