the short half-life of terbutaline sulphate (tbs) requires frequent dosing for controlling chronic pulmanary disorders, such as night asthma. the purpose of the present study was to prepare sustained-release (sr) tablets of tbs to decrease the number of doses frequency and to promote the paitent compliances. it was also desirable to evaluate the capability of natural gums for preparation of sr ...

peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

The phenomenon of 'weathering' of polymeric materials is usually caused by a complex series of chemical reactions initiated by the absorption of ultra-violet light which ultimately result in the deterioration of the physical properties of the polymer. One of the most likely initiating sites for ultraviolet absorption in polymers is the ketone carbonyl group which is often introduced into the po...

Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number ...

Object: The objective of the present study was to investigate the effect of various concentrations of natural and synthetic polymers on in vitro drug release from sustained release matrix tablets. Materials and method: HPMC K4M and acacia gum were used as synthetic (hydrophilic) and natural (hydrophobic) polymers respectively. Diclofenac sodium was used as a model drug to study the in vitro rel...

We study the swelling of a flexible linear chain composed of active particles by analytical theory and computer simulation. Three different situations are considered: a free chain, a chain confined to an external harmonic trap, and a chain dragged at one end. First, we consider an ideal chain with harmonic springs and no excluded volume between the monomers. The Rouse model of polymers is gener...

To the astrobiologist, Enceladus offers easy access to a potential subsurface biosphere via the intermediacy of a plume of water emerging directly into space. A direct question follows: If we were to collect a sample of this plume, what in that sample, through its presence or its absence, would suggest the presence and/or absence of life in this exotic locale? This question is, of course, relev...

Polymers as an adjuvant are capable of enhancing the vaccine potential against various infectious diseases and also are being used to study the actual autoimmune responses using self-antigen(s) without involving any major immune deviation. Several natural polysaccharides and their derivatives originating from microbes and plants have been tested for their adjuvant potential. Similarly, numerous...

thyme essential oils (eo) with antimicrobial and antioxidant properties are widely used in pharmaceutical, cosmetic, and perfume industry. it is also used for flavoring and preservation of several foods. nowadays, packaging research is receiving a considerable attention due to the development of eco-friendly materials made from natural polymers such as starch and chitosan. in this study thymus ...