OBJECTIVES To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. DESIGN Prospective study. SETTING Tertiary academic institution. PATIENTS Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal contr...

Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, was reported by Schirmer, Sturge and Weber in succession in mid-19th century. And it is a neurocutaneous disease classically presenting with a facial portwine stain in the ophthalmic distribution of the trigeminal nerve, glaucoma and vascular eye abnormalities, and an ipsilateral occipital leptomeningeal angioma. It is...

INTRODUCTION Nasal polyps are polypoidal masses arising from mucous membranes of nose and paranasal sinuses. They are overgrowths of the mucosa that frequently accompany allergic rhinitis. They are freely movable and nontender. AIMS AND OBJECTIVES The purpose of this study was to study the histopathologic spectrum of polypoidal lesions of the nasal cavity. MATERIALS AND METHODS The study co...

INTRODUCTION Cyclooxygenases 1 (Cox-1) and 2 (Cox-2) play a key role in arachidonic acid metabolism and in the regulation of eicosanoid production. The balance of prostaglandin and leukotrien release in respiratory mucosa is a crucial factor in the development of Sampter's triad in NSAID (aspirin-) intolerant patients and possibly also relevant in the pathophysiology and immunology of chronic r...

Detection and complete removal of precancerous neoplastic polyps are central to effective colorectal cancer screening. The prevalence of neoplastic polyps in the screening population in the United States is likely >50%. However, most persons with neoplastic polyps are never destined to develop cancer, and do not benefit for finding and removing polyps, and may only be harmed by the procedure. F...

PURPOSE OF REVIEW The purpose of this review is to highlight recent advances in gene-expression profiling of nasal polyps in patients with chronic rhinosinusitis and aspirin-sensitive asthma. RECENT FINDINGS Gene-expression profiling has allowed simultaneous interrogation of thousands of genes, including the entire genome, to better understand distinct biological and clinical phenotypes assoc...

Aim: To see the prevalence of fungal rhino sinusitis in patients presenting with nasal polyposis. Study design: Cross-sectional study. Place and duration study: Department Otorhinolaryngology Head Neck surgery, PIMS, Islamabad from 1st October 2021 to 31st March 2022. Methodology: Patients polyps fulfilling our inclusion criterion ENT PIMS. Eighty for surgery after admitting them specimen was s...