Introduction: Spontaneous Perforation of the nasal septum is an uncommon condition. Nasal inhalation of substances such as cocaine has long been linked to this Perforation. Case Report: This report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.This is the first reported case of nasal septal necrosis linked to...

In the undertaken study cross linked egg albumin microspheres of progesterone (PG) have been investigated through the nasal route. A smooth, spherical, cross-linked egg albumin microsphere in the size range of 15-37 μm loaded with progesterone were prepared by multiple emulsion (o/w/o) method by glutarldehyde cross-linking and thermal denaturation techniques. Microspheres were prepared by using...

A human nasal cavity was reconstructed from CT scans to make a Computational Fluid Dynamics (CFD) model. With this model, fluid flow and inhalation of aerosol analysis can be investigated. The surface of the interior nasal cavity is lined with highly vascularised mucosa which provides a means for direct drug delivery into the blood stream. Typical sprayed particles from a nasal spray device pro...

Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of drug delivery and therapy. Transporters are expressed differentially on the cell-surface of different cell types, and also specific transporters are expressed at higher than normal levels in selective cell types under pathological conditio...

The purpose of research work was to develop and optimize mucoadhesive microspheres of glibenclamide incorporated in in-situ gel for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy. Chitosan (mucoadhesive) based microspheres of glibenclamide were prepared by emulsificationcrosslinking method. Glutaraldehyde was used as crosslinking agent. A 32 factorial...