Molting is required for progression between larval stages in the life cycle of nematodes. We have identified four mutant alleles of a Caenorhabditis elegans metalloprotease gene, nas-37, that cause incomplete ecdysis. At each molt the cuticle fails to open sufficiently at the anterior end and the partially shed cuticle is dragged behind the animal. The gene is expressed in hypodermal cells 4 ho...

BACKGROUND A complex network of putative molecular interactions underlies the architecture and function of cell-matrix adhesions. Most of these interactions are implicated from coimmunoprecipitation studies using expressed components, but few have been demonstrated or characterized functionally in living cells. RESULTS We introduce fluorescence fluctuation methods to determine, at high spatia...

DEFINITION: The NAS Parallel Benchmarks (NPB) are a suite of parallel computer performance benchmarks. They were originally developed at the NASA Ames Research Center in 1991 to assess high-end parallel supercomputers [?]. Although they are no longer used as widely as they once were for comparing high-end system performance, they continue to be studied and analyzed a great deal in the high-perf...

BACKGROUND While schizophrenia is generally considered a neurodevelopment disorder, our basic understanding of the biochemical processes involved in disease etiology and/or progression is limited. One class of biochemical mediators that has been suggested to play a role in the development of schizophrenia is N-acyl ethanolamine metabolites of N-acylphosphatidylethanolamines. However, no investi...

Neonatal abstinence syndrome (NAS) is suffered by infants withdrawing from substances on which they have become physically dependent after in utero exposure. They may require prolonged treatment and spend weeks or even months in hospital. A wide range of drugs have been used to treat NAS. The efficacy of few, however, have been adequately investigated. Evidence suggests that opioids are the mos...

product/device. Abstract Infants exposed to opioids in utero and postnatally are at risk for developing withdrawal symptoms upon discontinuation of the drugs. This condition is known as the neonatal abstinence syndrome (NAS). Different medications have been used to ameliorate the symptoms of withdrawal, most commonly opioids. Clonidine has also been evaluated both as an additive and alternative...

Non-aureus staphylococci (NAS) are most commonly isolated from subclinical mastitis. Different NAS species may, however, have diverse effects on the inflammatory response in the udder. We determined the genome sequences of 20 staphylococcal isolates from clinical or subclinical bovine mastitis, belonging to the NAS species Staphylococcus agnetis, S. chromogenes, and S. simulans, and focused on ...

AIMS More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) of severity to require pharmacological therapy. Current treatments are associated with prolonged hospitalization. We sought to optimize the dose of sublingual buprenorphine in the treatment of NAS. DESIGN Randomized, Phase 1, open-label, active-control clinical trial comparing sublingual bupr...

Non-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumpt...

This paper presents a piecewise framework for network awareness service (NAS) for wireless/mobile pervasive computing. We investigate how piecewise consideration of wired and wireless elements of the framework architecture benefits service advertisement and discovery and network-awareness techniques. We also discuss scalability of the NAS framework with respect to platform computing capabilitie...