Opioid dependence is a major health problem and a cause of increasing concern to physicians and other health professionals worldwide. A crucial first step in intervention is detoxification. Recent trends in medical practice have seen the emergence of newer techniques that claim to accelerate the detoxification procedure and ensure prevention of relapse by rapid induction onto maintenance treatm...

OBJECTIVE To prospectively assess if opiate antagonist treatment or the opiate-free status could reverse opiate-related vasculopathy. DESIGN Longitudinal Open Observational, Serial 'N of One', over 6.5 years under various treatment conditions: opiate dependence, naltrexone and opiate-free. SETTING Primary care, Australia. PARTICIPANTS 20 opiate-dependent patients (16 males: 16 cases of bu...

It may sound a little nutty, but your friends are partially correct. Nutmeg, a spice commonly used to flavor lattes, sweets, and other foods has also been reported to produce a high that is similar to the one obtained with marijuana. Originating from the Myristica fragans tree in Indonesia, the seed is now grown and used globally, mostly for cooking but sometimes as a narcotic. However, for the...

Opioid maintenance treatment is the first-line approach in opioid dependence. Both the full opioid agonist methadone (MET) and the partial agonist buprenorphine (BUP) are licensed for the treatment of opioid dependence. BUP differs significantly from MET in its pharmacology, side effects, and safety issues. For example, the risk of respiratory depression is lower than with MET. The risk of dive...

It may sound a little nutty, but your friends are partially correct. Nutmeg, a spice commonly used to flavor lattes, sweets, and other foods has also been reported to produce a high that is similar to the one obtained with marijuana. Originating from the Myristica fragans tree in Indonesia, the seed is now grown and used globally, mostly for cooking but sometimes as a narcotic. However, for the...

OBJECTIVE Studies have consistently shown that long-term meditation practice is associated with reduced pain, but the neural mechanisms by which long-term meditation practice reduces pain remain unclear. This study tested endogenous opioid involvement in meditation analgesia associated with long-term meditation practice. METHODS Electrical pain was induced with randomized, double-blind, cross...

Introduction The increasing prevalence of cannabis use in the world requires awareness cannabis-related disorders such as cannabinoid hyperemesis syndrome (CHS). CHS is characterized by cyclic episodes nausea, vomiting and abdominal pain, affecting chronic users, who usually recur to hot showers relief symptoms. pathophysiology underlying this still unclear. Despite well-established anti-emetic...

Nootropic drug nefiracetam and related compounds are used in diseases with learning and memory deficits. Recent studies have implicated relationships between learning, memory, and chronic pain. Thus, in the present report, we have studied the effects of nootropic drug nefiracetam on the thermal and mechanical hyperalgesia induced by partial sciatic nerve ligation or streptozotocin treatment in ...

BACKGROUND Growing evidence demonstrates the adverse effects of narcotics in inflammatory bowel disease (IBD). We sought to study the relationship between narcotic use, objective measures of disease activity, and other associated factors in hospitalized patients with IBD. METHODS We performed a retrospective cohort study of all adult IBD patients admitted to a general medical or surgical ward...

background: narcotic abuse by people accounts for major problems for developing countries such as iran. acute narcotic poisoning is one of the major mortality causes in these patients. the present study was designed to assess the clinical signs and symptoms of patients with narcotic poisoning at hospitals of yazd. methods: in this study, 500 patients with narcotic poisoning were assessed from n...