We have successfully prepared α-Fe2O3 nanospheres by solvothermal method using 2-butanone and water mixture solvent for the first time, which were about 100 nm in diameter and composed of very small nanoparticles. The as-prepared samples were characterized using X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The results showed that the product was α-Fe2O3...

Employment or Leadership: None declared. Consultant or Advisory Role: P.A. Kavsak, Ortho Clinical Diagnostics; A.R. MacRae, Beckman Coulter; A.S. Jaffe, Beckman Coulter, Siemens, Ortho Diagnostics, Singulex, Nanosphere, Inverness, Critical Diagnostics, GSK, Merck, and Hoffman-LaRoche. Stock Ownership: None declared. Honoraria: P.A. Kavsak, Beckman Coulter. Research Funding: Canadian Institutes ...

The interest in micro- and nano-devices based on biodegradable polymers for in vivo applications is growing rapidly and the key to these applications lies in the fashioning of features analogous to the size of cells. This paper presents fabrication techniques for leveraging micro- and nanostructures on biodegradable polymers. Innovative approaches such as replication molding, laser interference...

We investigate optical excitations on single silver nanospheres and nanosphere composites with the Finite Difference Time Domain (FDTD) method. Our objective is to achieve polarization control of the enhanced local field, pertinent to SERS applications. We employ dimer and quadrumer structures, which can display broadband and highly confined near-field-intensity enhancement comparable to or exc...

Chemical doping with foreign atoms is an effective approach to significantly enhance the electrochemical performance of the carbon materials. Herein, sulfur-doped three-dimensional (3D) porous reduced graphene oxide (RGO) hollow nanosphere frameworks (S-PGHS) are fabricated by directly annealing graphene oxide (GO)-encapsulated amino-modified SiO2 nanoparticles with dibenzyl disulfide (DBDS), f...

c-myb antisense oligonucleotides (AS ODNs) were reversibly immobilized to a novel polymeric core shell nanosphere and their cellular uptake and inhibitory effect on HL60 leukemia cell proliferation studied. The nanosphere surface was so designed as to directly bind ODNs via ionic interactions and reversibly release them inside the cells. Compared with the cellular uptake of free oligonucleotide...

The challenges faced to orally deliver therapeutic agents with unfavorable physicochemical properties, such as proteins, have been the primary motivation for the design and development of novel oral delivery systems that could circumvent biological barriers. In this work, we examined complexation-sensitive hydrogel nanospheres composed of poly[methacrylic acid-grafted-poly(ethylene glycol)] (P(...