This report compares the effect of lipid and polymeric nanoparticles upon human neutrophils in the presence of cationic surfactants. Nanostructured lipid carriers and poly(lactic-co-glycolic) acid nanoparticles were manufactured as lipid and polymeric systems, respectively. Some cytotoxic and proinflammatory mediators such as lactate dehydrogenase (LDH), elastase, O2(•-), and intracellular Ca(2...

Multiple layer nanoparticles offers a likelihood of success in drug delivery, as it provides a solution for a more controllable drug release, as with such structures, control over the capsule wall thickness, permeability, stability, and degradation characteristics can be achieved (Kumar, 2008). Using PDMS microfluidic devices to synthesize polymeric multilayer microparticles has become popular ...

Biodegradable nanoparticles containing salmon calcitonin (sCT) were formulated using protein-fatty acid complexes, and their in vitro transport against a Caco-2 cell monolayer and the extent of in vivo oral uptake were assessed. Positively charged sCT was hydrophobically ion paired to form physical complexes with fatty acid, phospholipid, and surfactant. Among the complexes, sodium oleate was u...

We report the synthesis and optical properties of organic porphyrin nanoparticles with narrow size distribution and good dispersibility. Nanoparticles were produced by a combination of precipitation and sonication, termed the "ultrasonic method". The resulting [tetrakis(para-chlorophenyl)porphyrin]TClPP nanoparticles were stable in solution without precipitation for at least 30 days. No self ag...

in the past decades, many methods have been developed to synthesize zero- dimensional  nanoparticles, quasi–one–dimensional (1d) cuo nanostructures, such as metal organic deposition technique,  microwave irradiation, sol-gel-like dip  technique, reverse micelle-assisted route, chemical method, and simple template free solution route. among those synthesis methods, hydrothermal and chemical reac...

Over the past two decades, the taxanes have played a significant role in the treatment of various malignancies. However, the poor solubility of these compounds necessitates the inclusion of surfactant vehicles in their commercial formulations. Cremophor EL and polysorbate 80 have long comprised the standard solvent system for paclitaxel and docetaxel, respectively. A number of pharmacologic and...

Finely dispersed sandwich composite nanoparticles of Cu–Ni–Cu were prepared by a novel method combining template synthesis and an ultrasonic treatment method. The composite nanoparticles have uniform cylinder shape with tunable diameter and length. Transmission electron microscopy (TEM) and electron diffraction (ED) were employed to characterize the nanoparticles. This method can be used to fab...

A room temperature surfactant-free synthesis of gold nanoparticles in the size range 10–20 nm that only requires HAuCl4 as precursor, NaOH base, water solvent and a mono-alcohol such methanol or ethanol reducing agent, has recently been detailed. This approach is promisingly simple to obtain colloids stable for months. Here, it shown use fresh stock solutions base one key ensure formation small...

In this Letter, dynamic wetting of water nano-droplets containing non-surfactant gold nanoparticles on a gold substrate is examined via molecular dynamics simulations. The results show that the addition of non-surfactant nanoparticles hinders the nano-second droplet wetting process, attributed to the increases in both surface tension of the nanofluid and friction between nanofluid and substrate...