Extracellular vesicles (EVs) are nano-sized, membrane-enclosed released by cells for intercellular communication. EVs involved in pathological processes and miRNAs have gained interest as easily accessible biomolecules liquid biopsies diagnostic purposes. To validate potential miRNA biomarker, transcriptome analyses must be carried out to detect suitable reference miRNAs. miREV is a database wi...

background: the study was performed to investigate the effects of morphine dependency and morphine withdrawal on the reproductive system of adult male rat(wistar).  methods: 32 adult male rat divided into 5 groups. animals in the control group (n=8) received normal saline (1ml/kg) twice daily subcutaneously for 30 consecutive days. animals in dependent group (n=8) received morphine (10mg/ml/kg)...

AIM The study investigates the effects of magnesium nanovesicles on the memory processes performance in mice. MATERIALS AND METHODS L-a-phosphatidylcholine was used to obtain nano formulations as lipid vesicles systems stabilized thereafter with chitosan. The experiment was carried out on white Swiss mice, divided into 3 groups of 7 animals each, treated orally 7 consecutive days: Group I (Co...

Extracellular vesicles are small membrane-derived packages of information that released from virtually all cell types. These nano-packages contain regulatory material including proteins, lipids, mRNA and microRNA a key mechanism paracellular communication within given microenvironment. Encompassed with lipid bilayer, these organelles have been attributed numerous roles in regulating both physio...