Nowadays, a real challenge in cancer therapy is to design drug delivery systems that can achieve high concentrations of drugs at the target site for improved therapeutic effect with reduced side effects. In this research, we designed and synthesized a homing peptide-(TNYLFSPNGPIA, TNYL) modified chitosan-g-stearate (CS) polymer micelle (named T-CS) for targeting delivery. The peptide displayed ...

This study was carried out to investigate an effective method for the co-delivery of Gemcitabine (GEM) and paclitaxel (PTX) into tumor cells. GEM and PTX were modified with functional (+)-a-tocopherol (VE) to obtain similar water solubility. Folic acid-poly(ethylene glycol)–(+)-a-tocopherol (FA–PEG–VE) was designed to co-encapsulate the modified GEM and PTX. Methoxy poly(ethylene glycol)–poly(l...

Islet transplantation is one of many therapeutic approaches for the treatment of diabetes. During transplant procedures, the isolated islets are subjected to hypoxic conditions, and undergo the apoptotic process. Curcumin has a cytoprotective effect, and may therefore be useful for the protection of islets under hypoxia. However, curcumin is hydrophobic, and an efficient curcumin carrier is req...

Age and diabetes related slow-healing or chronic wounds may result in morbidity mortality through persistent biofilms infections prolonged inflammatory phase. Nano-materials [metal/metal oxide NPs (39%), lipid vehicles (21%), polymer (19%), ceramic nanoparticles (NPs) (14%), carbon nanomaterials (NMs) (7%)] can be introduced as a possible next-generation therapy because of either their intrinsi...

Abstract Decreasing the salivary flow rate manifested by xerostomia occurs early during irradiation treatment. The duration of depressed function varies among patients. Various histopathological changes occur in glands. current study was performed to investigate and compare between possible anti-radiotherapeutic effect gamma rays-synthesized curcumin nanoparticles (Cur NPs), chitosan (Cs NPs). ...

objective(s) doxorubicin (dox), a widely used chemotherapeutic agent can give rise to serve cardiotoxicity by inducing apoptosis. curcumin, the active compound of the rhizome of curcuma longa l. has anti-inflammatory, antioxidant and anti-proliferative activities. curcumin has been identified to increase cytotoxicity in several cancer cell lines in combination with dox, but there is no study ab...

Nanoemulsion-based delivery systems have a considerable potential for the encapsulation, protection and of lipophilic bioactives. In current study, in-vitro stability curcumin-loaded single (NEI), double (NEII), triple-layered nanostructures was investigated against varying environmental stress (temperature, pH, ionic strength) storage conditions. addition, their functional performance, as infl...

The problem of poor bioavailability and clinical efficacy of curcumin can be sorted out after converting crystalline Curcumin (CrysCur) into amorphous NanoCurcumin (NanoCur). Amorphous NanoCur was prepared by converting into nanoemulsion (o/w) using water titration method. The formulation were pre-screen by different physical stress tests, followed by in vitro release study, zeta potential, vis...