poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. proper diagnosis is the cornerstone for optimal management of poisoned patients. since the definitive analytical confirmation of the nature of the toxicant involved in the poisoning cannot be rapidly obtained in the majority of healthcare facilities, diagnosis relies on the medical histo...

The effects of steady-state faldaprevir on the safety, pharmacokinetics, and pharmacodynamics of steady-state methadone and buprenorphine-naloxone were assessed in 34 healthy male and female subjects receiving stable addiction management therapy. Subjects continued receiving a stable oral dose of either methadone (up to a maximum dose of 180 mg per day) or buprenorphine-naloxone (up to a maximu...

Opiate overdose produces pinpoint pupils and varying degrees of respiratory depression and impairment of consciousness. If there is coma or bradypnoea, the opiate antagonist naloxone should be given intravenously. If the patient has taken a long-acting opioid such as methadone, a naloxone infusion should be considered1. After the administration of naloxone, opiate-dependent patients will experi...

Objective This study was initiated to investigate the effect of Portulaca oleraceae on morphine dependence in mice. Materials and Methods Dependence was induced using the subcutaneous injections of morphine for 3 days. On the day 4, morphine injected 2 h prior to intraperitoneal injection of naloxone. The plant extracts ethanolic or aqueous administered 0.5 h before the final dose of morphine. ...

Opioid dependence in ventrolateral periaqueductal gray (PAG) neurons was studied by using intracellular recordings from brain slices. In slices from morphine-dependent rats maintained in morphine (5 microM) in vitro, action potential frequencies of opioid-sensitive neurons did not differ from untreated control neurons but were greater than in control neurons maintained in morphine in vitro, ind...

OBJECTIVES We examined the use, procurement, and motivations for the use of diverted buprenorphine/naloxone among injecting and noninjecting opioid users in an urban area. METHODS A survey was self-administered among 51 injecting opioid users and 49 noninjecting opioid users in Providence, RI. Participants were recruited from a fixed-site syringe exchange program and a community outreach site...

introduction: opiates cause dependency via affect on central nervous system. locus coeruleus nucleus is a main group of noradrenergic neurons in the brain that plays an important role in the expression of opioid withdrawal signs. during opioid withdrawal, brain waves change in addition to physical and behavioral signs. in this study, we examined the effects of locus coeruleus electrical stimula...

Single-cell activity was recorded in the locus coeruleus (LC) of morphine-dependent, halothane-anesthetized rats. Systemic administration opiate antagonist naloxone (0.1 mg/kg, i.v.) robustly increased LC neurons. Local microinjection or its hydrophilic derivative, methiodide, into (10 mM, 20-40 nl) did not activate neurons dependent Intracerebroventricular intracoerulear injection kynurenate, ...

BACKGROUND AND AIM Potentially life-threatening and unpleasant side effects associated with some analgesics have fueled the drive for the search for more analgesics with better side effect profiles. Geraniin, the most dominant secondary metabolite in the aqueous extract of the aerial parts of Phyllanthus muellerianus, has been shown to possess antinociceptive properties mediated partly by opioi...

This study was designed to examine the effect of environmental enrichment during morphine dependency and withdrawal on the severity of naloxone-precipitated withdrawal signs, anxiety, and depressive-like behaviors and voluntary morphine consumption in morphine-dependent rats. The rats were injected with bi-daily doses (10 mg/kg, 12 h intervals) of morphine for 14 days following rearing in a sta...