نتایج جستجو برای: naloxone
تعداد نتایج: 4623 فیلتر نتایج به سال:
To clarify the involvement of the opioid system in enhanced immunosuppression induced by heat stress during pregnancy, we examined the effects of heat exposure and intraperitoneal administration of opioid receptor antagonist naloxone on β-endorphin (β-EP) in blood, pituitary lobes, and placenta as well as splenic natural killer cell activity (NKCA) and placental steroids in pregnant rats at 15-...
introduction: formalin injection induces nociceptive bahaviour in phase i and ii, with a quiescent phase between them. while active inhibitory mechanisms are proposed to be responsible for initiation of interphase, the exact mechanisms which lead to termination of nociceptive response in phase ii are not clear yet. phase ii is a consequence of peripheral and central sensitization processes, whi...
BACKGROUND Opioid overdose is a leading cause of accidental death in the United States. OBJECTIVE To estimate the cost-effectiveness of distributing naloxone, an opioid antagonist, to heroin users for use at witnessed overdoses. DESIGN Integrated Markov and decision analytic model using deterministic and probabilistic analyses and incorporating recurrent overdoses and a secondary analysis a...
Non-fatal overdose is an occupational risk of heroin misuse' and fatal overdose is a common cause of premature death in heroin users. ... One of the major contributors to a fatal outcome is the inadequacy of heroin users' responses to the overdoses of their peers. They may delay calling an ambulance for fear of the police arriving, and their efforts to revive comatose users are often ineffectiv...
Heat shock protein (HSP)60 is primarily a mitochondrial protein. Previous experiments have found that changes in the location of intracellular HSP60 have been associated with apoptosis. Extracellular HSP60 mediates apoptosis via its ligand, Toll-like receptor (TLR)-4. TLR-4 is an important factor expressed on microglia, with a central role in generating neuroimmune responses in the pathogenesis...
BACKGROUND AND AIMS Fatal outcome of opioid overdose, once detected, is preventable through timely administration of the antidote naloxone. Take-home naloxone provision directly to opioid users for emergency use has been implemented recently in more than 15 countries worldwide, albeit mainly as pilot schemes and without formal evaluation. This systematic review assesses the effectiveness of tak...
Four ruminally cannulated Holstein heifers (287 +/- 26 kg) in a 4 x 4 Latin square were used to evaluate the effects of naloxone injection and forage level on dietary intake, ruminal fermentation characteristics, digestibility, and plasma hormone and metabolite concentrations. Treatments were arranged in a 2 x 2 factorial with naloxone injection (0 vs .3 mg/kg; saline vs naloxone, respectively)...
BACKGROUND To reduce fatal drug overdoses, two approaches many states have followed is to pass laws expanding naloxone access and Good Samaritan protections for lay persons with high likelihood to respond to an opioid overdose. Most prior research has examined attitudes and knowledge among lay responders in large metropolitan areas who actively use illicit substances. The present study addresse...
CONTEXT No randomized trials have examined treatments for prescription opioid dependence, despite its increasing prevalence. OBJECTIVE To evaluate the efficacy of brief and extended buprenorphine hydrochloride-naloxone hydrochloride treatment, with different counseling intensities, for patients dependent on prescription opioids. DESIGN Multisite, randomized clinical trial using a 2-phase ad...
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