Background—Adeno-associated virus type 1/sarcoplasmic reticulum Ca 2ϩ-ATPase was assessed in a randomized, double-blind, placebo-controlled, phase 2 study in patients with advanced heart failure. Methods and Results—Thirty-nine patients received intracoronary adeno-associated virus type 1/sarcoplasmic reticulum Ca 2ϩ-ATPase or placebo. Seven efficacy parameters were assessed in 4 domains: sympt...

Neuropeptides regulate cell-cell signaling and influence many biological processes in vertebrates, including development, growth, and reproduction. The complex processing of neuropeptides from prohormone proteins by prohormone convertases, combined with the evolutionary distance between the chicken and mammalian species that have experienced extensive neuropeptide research, has led to the empir...

There are currently no accepted and validated blood tests available for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In this study, we sought to determine the discriminatory power of blood C-reactive protein (CRP) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) in the diagnosis of AECOPD requiring hospitalizations. The study cohort consisted ...

The aim of the study was to determine risk factors for occurrence acute heart failure (AHF) high degrees (Killip classes III and IV) among patients with myocardial infarction (MI).
 Materials methods. We examined 308 MI who were treated at specialized cardiology department. mean age subjects 62.9±0.6 years. There 161 (52.3%) without signs (HF) class I), 44 (14.3%) combined II AHF, 55 (17.8...

BACKGROUND AND PURPOSE Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content. Therefore, to determine the role of endogenous arginine vasopressin in brain edema, we attempted to inhibit edema from a hemorrhagic lesion with an arginine vasopressin V1 receptor antagon...

Natriuretic Peptide: A Probable Culprit in Prevention of Primary Cardiovascular Diseases Using β-Blockers To the Editor: This letter refers to “The Value of N-Terminal Pro-B-Type Natriuretic Peptide in Determining Antihypertensive Benefit: Observations From the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)” by Welsh et al1 The 2014 evidence-based guideline for the management of high blood p...

NT-proBNP is produced from both atria and ventricles. The primary regulation of production is at the synthesis level. The plasma half-life of NT-proBNP is 60-120 min. Cutoff value of NT-proBNP for diagnosis of heart failure is 125 pg/ml in the age group below 75 years and 450 pg/ml in the age group above 75 years. It increases in atrial fibrillation and drops after successful cardioversion. Hig...