./V-acetoxy-acetylaminofluorene; but no increase was demon strated when cells were treated with ./V-nitrosodiethylamine, yV-nitrosodimethylamine, or 2-acetylaminofluorene. The frequency of viral transformation increased linearly with chemical concentration until a maximum level was reached; however, higher concentrations decreased the trans formation frequency relative to that observed with low...

Volatile nitrosamines (VNAs) are a group of compounds classified as probable (group 2A) and possible (group 2B) carcinogens in humans. Along with certain foods and contaminated drinking water, VNAs are detected at high levels in tobacco products and in both mainstream and sidestream smoke. Our laboratory monitors six urinary VNAs-N-nitrosodimethylamine (NDMA), N-nitrosomethylethylamine (NMEA), ...

Metabolic activation may be a key step in determining the tissue specificity of carcinogenic nitrosamines. In previous work, we characterized P450IIE1 (an acetone/ethanol-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. In this work, we investigated the metabolism of other N-nitrosodialkylamines in rat liver microsomes and in recons...

SUMMARY 1-Methyl-l-nitrosourea (MNU), the active moiety of the Streptozotocin molecule, produces a dose-related depression of nicotinamide adenine dinucleotide (NAD) concentrations in mouse liver and L1210 ascities, similar to that produced by the latter compound. There was early increase in liver NAD glycohydrolase activity, but no significant change in NAD pyrophosphorylase. While pretreatmen...

Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most xenobiotics harm their target in a repetitive or chronic manner. Therefore, we propose a model, which provides repetitive incubations in human up...

This study reports the synthesis and characterization of tungsten trioxide-based catalysts for photocatalytic degradation N-nitrosodiethylamine (NDEA) in wastewater. Tungsten trioxide (WO3) was synthesized using thermal treatment method (TTM) hard template replication (HTRM) impregnated with lanthanum (La), iron (Fe), chromium (Cr), silver (Ag) to enhance its light absorption ability. The were ...

conclusions nitrosamine was formed with conventional potato baking methods with the most nitrosamine formation found on the surface fried samples. nitrites amount in baked potatoes decreased. generally, the amount of nitrosamine in baked potato samples was lower than acceptable limits. results fried samples that were measured by the gas chromatography method had the highest average levels of ni...

./V-acetoxy-acetylaminofluorene; but no increase was demon strated when cells were treated with ./V-nitrosodiethylamine, yV-nitrosodimethylamine, or 2-acetylaminofluorene. The frequency of viral transformation increased linearly with chemical concentration until a maximum level was reached; however, higher concentrations decreased the trans formation frequency relative to that observed with low...

A new technique, using an oscillating viscometer capable of measuring changes of DNA reduced viscosity (eta red), has been used to detect DNA damage in liver of rats treated with various chemical carcinogens. In denaturing conditions (pH 12.5), the eta red of liver DNA from control rats increased slowly with time, reaching a maximum, (eta red)max, after 10 to 13 hr. Single i.p. doses of N-nitro...