Synthetic and natural polymers are often used as drug delivery systems in vitro and in vivo. Biodegradable chitosan of different sizes were used to encapsulate antitumor drug tamoxifen (Tam) and its metabolites 4-hydroxytamoxifen (4-Hydroxytam) and endoxifen (Endox). The interactions of tamoxifen and its metabolites with chitosan 15, 100 and 200 KD were investigated in aqueous solution, using F...

An axially chiral N,N′-bisindole is shown on the cover picture, representing one of fruits tree indole chemistry. In their Research Article (e202300419), Yu-Chen Zhang, Feng Shi, and co-workers describe organocatalytic enantioselective construction scaffold with promising applications in medicinal chemistry asymmetric catalysis. Aptamers Carbon Dioxide Capture Batteries Photocatalysis

The g-puzzle and the 15puzzle have been used for many years as a domain for testing heuristic search techniques. From experience it is known that these puzzles are “difficult” and therefore useful for testing search techniques. In this paper we give strong evidence that these puzzles are indeed good test problems. We extend the 8puzzle and the Epuzzle to a nxn board and show that finding a shor...