We tested the hypothesis that endothelin acting through the endothelial ET(B) receptor subtype and the nitric oxide (NO) pathway accounts for reduced myogenic reactivity of the renal resistance vasculature during pregnancy. Small renal arteries (100-200 microm) were isolated from virgin and midterm pregnant rats when gestational renal hyperfiltration and vasodilation are maximal in this species...

The objectives of this study were to evaluate the myogenic behavior of blood vessels and their interaction within the coronary arterial tree and to evaluate the possible role of the myogenic response in autoregulation. The model consists of 10 compartments in series, each representing a class of vessel sizes. Diameter and resistance in each class are determined by their value at full dilation (...

Myogenic differentiation in adult muscle is normally suppressed and can be activated by myogenic cues in a subset of activated satellite cells. The switch mechanism that turns myogenesis on and off is not defined. In the present study, we demonstrate that tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of TNFalpha-converting enzyme (TACE), acts as an on-off switch for ...

We tested the hypothesis that lymphatics would exhibit myogenic constrictions and dilations to intraluminal pressure changes. Collecting lymphatic vessels were isolated from rat mesentery, cannulated, and pressurized for in vitro study. The lymphatic diameter responses to controlled intraluminal pressure steps of different magnitudes were tested in the absence and presence of the inflammatory m...

background and aim: autoimmune inner ear disease (aied) may accompany certain systemic conditions, such as rheumatoid arth­ritis, and manifest audiovestibular dysfunction. this study aimed to compare the vestibular function between rheumatoid arthritis (ra) patients and normal subjects using cervical vestibular-evoked myogenic potentials and caloric tests. methods: in this cross-sectional study...

background and aim: motion sickness (ms) is usually generated when there is a mismatch between the senses which serve balance. one of these senses is related to vestibular system, so it is highly possible that ms reflects in vestibular test results. but there are some conflicts in correlation between vestibular findings and ms. thus, the objective of this study was to provide an overview of ves...

background and aim: vestibular migraine is a type of migraine that causes vertigo, dizziness, and imbalance in addition to typical migraine symptoms. in this study, we aimed to investigate vestibular system in these patients by videonystagmography (vng), electrocochleography (ecochg), and vestibular evoked myogenic potential (vemp) testing. methods: this empirical study was conducted on 10 pati...

background: rheumatoid arthritis (ra) is an autoimmune systemic disease. most common autoimmune diseases are multisystem disorders that may also present with otological manifestations, and autoimmune inner ear disease accompanied by vestibular dysfunction. this study aimed to compare the vestibular function between ra patients and normal subjects using cervical vestibular evoked myogenic potent...

Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen with either myogenic bHLH factor alone. This cooperativity required direct inter...

The myogenic precursors responsible for muscle growth in amniotes develop from the dermomyotome, an epithelium at the external surface of the somite. In teleosts, the myogenic precursors responsible for growth have not been identified. We have used single cell lineage labeling in zebrafish to show that anterior border cells of epithelial somites are myogenic precursors responsible for zebrafish...