p160 coregulators were initially identified as nuclear hormone receptor coactivators. In this study, functional data demonstrate that members of the three p160 families can have opposing roles in regulating gene expression by the same transcription factor. Both SRC1A and p/CIP function as coactivators for MyoD-mediated transcription whereas GRIP1 acts negatively as a (co)repressor. SRC1A and p/...

Un niveau élevé d'acides gras saturés (AGS) dans le sang a un effet délétère sur les muscles squelettiques en inhibant à la fois régénération des fibres musculaires et synthèse protéines musculaires. Du fait de sa richesse AGS, l’huile palme est controversée. Cette étude avait pour objectif d’étudier l’effet d’un régime riche huile (brute raffinée) l’expression facteurs myogéniques muscle rats ...

To clarify the role of gravity in the postnatal development of skeletal muscle, we exposed neonatal rats at 7 days of age to microgravity. After 16 days of spaceflight, tibialis anterior, plantaris, medial gastrocnemius, and soleus muscles were removed from the hindlimb musculature and examined for the expression of MyoD-family transcription factors such as MyoD, myogenin, and MRF4. For this pu...

Krüppel-like factor 5 (Klf5) is a zinc-finger transcription factor that controls various biological processes, including cell proliferation and differentiation. We show that Klf5 is also an essential mediator of skeletal muscle regeneration and myogenic differentiation. During muscle regeneration after injury (cardiotoxin injection), Klf5 was induced in the nuclei of differentiating myoblasts a...

MyoD expression is thought to be induced in somites in response to factors released by surrounding tissues; however, reverse transcription-PCR and cell culture analyses indicate that myogenic cells are present in the embryo before somite formation. Fluorescently labeled DNA dendrimers were used to identify MyoD expressing cells in presomitic tissues in vivo. Subpopulations of MyoD positive cell...

the aim of this study was to investigate the effects of an acute bout of exhaustive resistance exercise on the expression of myogenesis modulators (myostatin (mstn) and myod) in male trained and untrained wistar rats’ fast and slow muscles. thirty rats were assigned to three groups: control (n=6), untrained (n=12) and trained (n=12). resistance exercise (weight lifting up a vertical ladder) was...

[Purpose] We reported that carbon dioxide (CO2) water bathing accelerates skeletal muscle regeneration; however, the underlying mechanism was unclear. MyoD and myogenin play roles in muscle regeneration, and the purpose of this study was to determine changes in MyoD and myogenin caused by CO2 water bathing after injury. [Subjects] Sixteen female Wistar rats (n = 4 per group) were used. [Methods...