Brief periods of ischemia not only cause a long lasting (hours to days) myocardial contractile dysfunction (stunning) but also increase the tolerance for irreversible damage during a subsequent ischemic episode, a phenomenon called ischemic preconditioning.1J Heat-shock proteins, in particular HSP-70, have been postulated in myocardial protection against irreversible damage due to i~chemia .~ I...

specific (tsubo-type) left ventriculographic configuration due to multivessel spasm. In: Kodama K, Haze K, Hori M, editors. Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure [in Japanese]. Tokyo: Kagakuhyouronsya, 1990:56–64. 3. Dote K, Sato H, Tateishi H, et al. Myocardial stunning due to simultaneous multivessel spasms: a review of 5 cases [in Japanese with English abstract...

Ischemic preconditioning (IP) was originally defined as the enhancement of myocardial tolerance against infarction induced by a brief sublethal episode of ischemia in experimental animals (1,2). Subsequently, the concept of IP was expanded and currently includes protection against myocardial stunning, arrhythmia, and vascular dysfunction after ischemia/reperfusion injury (3–6). Results of clini...

Acute aortic dissections are uncommon but highly mortal emergencies. Atypical presentations can be missed and delayed diagnoses may diminish favourable impact of medical, interventional and surgical procedures. Hereby we describe a painless aortic dissection case presented with heart failure due to functional obstruction of left main coronary artery resulting left ventricular dysfunction by pre...

INTRODUCTION Ischemic stroke has been associated with stunned myocardium and neurogenic pulmonary edema (NPE). We studied a population of patients with large vessel brainstem ischemic stroke to see if there was an increased risk of pulmonary edema associated with strokes in this region independent of myocardial stunning. HYPOTHESIS Large vessel ischemic strokes of the brainstem are associated...

BACKGROUND Mounting evidence suggests a protective effect of exogenous adenosine in myocardial ischemia and reperfusion. We tested the hypothesis that augmentation of endogenous adenosine levels, achieved by inhibiting adenosine catabolism and washout, is beneficial in postischemic myocardial dysfunction ("stunning"). METHODS AND RESULTS In phase I of the study, open-chest dogs undergoing a 1...