نتایج جستجو برای: myeloproliferative disorders

تعداد نتایج: 676333  

Journal: :The EMBO journal 2009
Paloma García Mary Clarke Alexandros Vegiopoulos Oscar Berlanga Ana Camelo Maelle Lorvellec Jon Frampton

Murine haematopoietic stem cells (HSCs) are contained in the Kit+Sca1+Lin(-) (KSL) population of bone marrow and are able to repopulate lethally irradiated mice. Myeloproliferative disorders (MPDs) are thought to be clonogenic diseases arising at the level of the HSC. Here, we show that mice expressing low levels of the transcription factor c-Myb, as the result of genetic knockdown, develop a t...

Journal: :Haemostasis 1986
P Viero S Cortelazzo T Barbui G de Gaetano

Platelets from 6 out of 10 patients with myeloproliferative disorders showed only a single reversible wave of aggregation when challenged with platelet activating factor (PAF). Preexposure to subthreshold concentrations of adrenaline resulted in a full irreversible response to PAF. Aspirin, however, removed this synergism. In the remaining 4 patients, PAF induced a full response but aspirin abo...

Journal: :Blood 1993
U Budde R E Scharf P Franke K Hartmann-Budde J Dent Z M Ruggeri

Twelve of 19 patients with myeloproliferative disorders showed a decrease of absence of the largest multimers of plasma von Willebrand factor (vWF) that correlated with elevated platelet counts but not with leukocyte counts. This suggested that platelets, rather than leukocytes, may be associated with the pathogenesis of the acquired vWF abnormality seen in these patients. To examine the hypoth...

Journal: :Clinical chemistry 2006
Julie Decock

References 1. Tyagi S, Kramer FR. Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 1996;14:303–8. 2. Petersen M, Wengel J. LNA: a versatile tool for therapeutics and genomics. Trends Biotechnol 2003;21:74–81. 3. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 200...

2014
Bing Li Robert Peter Gale Zhijian Xiao

According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress in our understanding of the molecular genetics of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms has made it clear that there are some specific genetic abnorm...

Journal: :Blood 1962
J I BRODY F RODRIGUEZ

By JEROME I. BRODY AND FERNANDO RODRIGUEZ T HE PURPOSE of this report is to describe two well-known clinical conditions which have not been associated specifically with the myeloproliferative syndromes. A recent clinical and patient-record review in this hospital discovered an apparent increase in diabetes mellitus and one example of scieroderma associated with this group of blood abnormalities...

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