A case of coexistent acute myeloid leukaemia and sarcoidosis is reported. This was complicated by recurrent pulmonary haemorrhage during reinduction and consolidation chemotherapy. A review of published papers on malignancy and sarcoidosis, in particular acute leukaemia is given. The outcome of most cases of acute leukaemia and sarcoidosis is poor with respiratory complications a frequent cause...

Tyrosol is a phenolic found in extra virgin olive oil (EVOO). In Maltese monocultivar EVOO, it was present at concentration of 9.23 ppm. The HL-60 acute myeloid leukaemia cell line, which can be differentiated to both monocytes and neutrophils, exposed tyrosol this analysed for evidence differentiation effects cytotoxicity. polyphenol induced 1.93-fold increase cellular oxidative activity (p-va...

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinosi...

Orbital or subconjunctival infiltration occurs frequently in acute and chronic lymphatic leukaemia, but only rarely in myelogenous leukaemia (Chatterjee and Sen, I 960). Chloroma, an atypical form of myeloblastic leukaemia, often manifests itself as a localized mass in the orbital periosteum, and the proptosis produced in such cases may be the first sign of the disease (Goodman and Iverson, I94...

Although leukaemic infiltration of the pericardium is frequently observed at post-mortem, clinically evident cardiac tamponade is rare. Two cases of cardiac tamponade complicating leukaemia are presented. One patient had cardiac tamponade as the initial presentation of acute lymphoblastic leukaemia and experienced complete resolution of the pericardial effusion within 6 days after chemotherapy ...

8. Koizumi H, Kumakiri M, Ishizuka M, Ohkawara A, Okabe S. Leukaemia cutis in acute myelomonocytic leukaemia: infiltration of minor traumas and scars. J Dermatol. 1991;18:281--5. 9. Kristensen IB, Moller H, Kjaershov MW, Yderstraede K, Moller MB, Bergmann OJ. Myeloid sarcoma developing in pre-existing pyoderma gangrenoso. Acta Derm Venereol. 2009;89:175--7. 10. Guinovart RM, Carrascosa JM, Ferr...

Clinics and pathology Disease Myeloid malignancies: myelodysplastic syndrome (MDS) in 1/4 of cases, with various FAB diagnoses (refractory anaemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)), acute non lymphocytic leukaemia (ANLL) in 60% of cases (M2-ANLL in 1/4 of all cases), blast crisi...

Granulocytic sarcomas of the small bowel are rare. They are discrete tumours of leukaemic myeloblasts and partially matured granulocytes that form in any part of the body. This disease is infrequently seen in patients with acute myeloid leukaemia, and rarely seen in patients without leukaemia. Here we report a case of small bowel obstruction due to granulocytic sarcoma of mid-ileum in a non-leu...

Pulmonary haemorrhage is a common necropsy finding in acute leukaemia, however, it is rarely diagnosed during life. A man with acute myeloid leukaemia is reported who presented with disseminated fungal infection, anaemia, thrombocytopenia, and subconjuctival and petechial haemorrhages. During the course of the patient's illness, the chest infection was complicated with bilateral pulmonary haemo...