نتایج جستجو برای: myc downstream
تعداد نتایج: 83881 فیلتر نتایج به سال:
Breast cancer is one of the most lethal malignancies in women worldwide and characterized by rapid growth low survival rates, despite advances tumor biology therapies. Novel therapeutic approaches require new insights into molecular mechanisms malignant transformation progression. To this end, here, we identified Prox1 as a negative regulator proliferation tumor-related metabolism breast cancer...
Congestion occurs at a bottleneck along an Internet path; multiple flows between the same sender and receiver can therefore benefit from using only a single congestion control instance when they share the same path. These benefits include the ability to perfectly control the rate allocation between flows. We present a mechanism for coupling congestion control for real-time media that is simpler...
Current treatments for hearing loss, the most common neurosensory disorder, do not restore perfect hearing. Regeneration of lost organ of Corti hair cells through forced cell cycle re-entry of supporting cells or through manipulation of stem cells, both avenues towards a permanent cure, require a more complete understanding of normal inner ear development, specifically the balance of proliferat...
Survival following anthracycline-based chemotherapy remains poor among patients with most T-cell lymphoproliferative disorders. This may be attributed, at least in part, to cell-autonomous mechanisms of chemotherapy resistance observed in these lymphomas, including the loss of important tumor suppressors and the activation of signaling cascades that culminate in the expression and activation of...
B cell lymphomas mainly arise from different developmental stages of B cells in germinal centers of secondary lymphoid tissue. There are a number of signaling pathways that affect the initiation and development of B cell lymphomagenesis. The functions of several key proteins that represent branching points of signaling networks are changed because of their aberrant expression, degradation, and/...
Myc oncogenic transcription factor is known to inhibit tumor suppressive microRNAs (miRNAs), resulting in greater expression of their target protein related to cell cycle, invasion or anti-apoptotic factors in human cancer cells. To explore possible oncogenic factors in Ewing's sarcoma (ES), we conducted microarray-based approach to profile the changes in the expression of miRNAs and its downst...
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