Purpose of the study Maraviroc (MVC), a CCR5 antagonist, does not appear to adversely affect serum lipids and may decrease LDL cholesterol in dyslipidemic subjects. The CCR5-del32 polymorphism, resulting in reduced (heterozygous) or absent (homozygous) CCR5 expression, is associated with reduced risk of cardiovascular disease. An early imbalance of cardiovascular adverse events was noted in the...

Methods Patients enrolled in the MERIT study (MVC or efavirenz plus zidovudine/lamivudine in treatment-naïve patients) with R5 virus at screening (by original Trofile assay) and randomized to the twice-daily MVC arm were included. UDS was performed with a 454/Roche GS-FLX instrument. Tropism was predicted using the “geno2pheno” co-receptor algorithm (g2p). A sample was considered R5 if <2% of v...

We present a detailed characterization of a single-cycle infection of the bocavirus minute virus of canines (MVC) in canine WRD cells. This has allowed identification of an additional smaller NS protein that derives from an mRNA spliced within the NS gene that had not been previously reported. In addition, we have identified a role for the viral NP1 protein during infection. NP1 is required for...

Maximum Voluntary Contraction(MVC) is frequently used in human machine muscle interfaces, especially the ones using Electromyography(EMG) and Acousticmyography(AMG). In some cases MVC alone is enough to adapt a system from one user to another, which could potentially create a simple system that any user could instantly use with minimal training and calibration. This research work evaluates the ...

Using (31)P magnetic resonance spectroscopy, creatine kinase (CK) reaction kinetics was assessed in the forearm flexor digitorum profundus muscle of healthy young (n = 11, age 34.7 +/- 5 yr) and older (n = 20, age 73.5 +/- 8 yr) subjects at rest, intermittent exercise at 20% maximum voluntary contraction (MVC), and 40% MVC. Exercise resulted in a significant increase in the average ratio of ino...

OBJECTIVE To assess quadriceps strength and fatigability by using femoral nerve magnetic stimulation (FNMS) and their relationship to exercise capacity in patients with fibromyalgia syndrome (FMS) and healthy controls. METHODS Twenty-two women (11 with FMS, 11 controls) performed a maximal incremental cycling test and a quadriceps fatigue test on 2 separate visits. For quadriceps assessment, ...

Maximal voluntary contraction (MVC) using a handgrip dynamometer was assessed in seventy-two young adult males. The subjects were divided into two groups on the basis of a BMI of 18.5 kg/m2. The subjects with a BMI < 18.5 kg/m2 (n 38) were further divided into an underweight (UW; n 20) group and a chronically energy-deficient (CED; n 18) group. The CED subjects had significantly lower MVC (30.1...

Although multiview video and its applications are becoming increasingly prevalent, there have been very limited researches on multiview video coding (MVC) specially combined with human visual system. To reduce computational complexity of MVC, a fast mode decision algorithm for MVC based on binocular just noticeable difference is proposed in this paper. A binocular just noticeable difference mod...

EMG-Driven models predict individual muscle forces, but it is necessary to obtain muscle electromyography (EMG), which is difficult for deep muscle, as vastus intermedius (VI). The purpose of this study is to determine the relative contribution of each quadriceps (QF) components to the knee extension torque by EMG-Driven model, with a protocol of surface VI EMG acquisition, at submaximal isomet...

Assays to identify infectious organisms are critical for diagnosis and enabling the development of therapeutic agents. The demonstration that individuals with a 32-bp deletion within the CCR5 locus were resistant to human immunodeficiency virus (HIV) infection, while those heterozygous for the mutation progressed more slowly, led to the discovery of maraviroc (MVC), a CCR5 antagonist. As MVC is...