BACKGROUND In neuromyelitis optica (NMO), one of the underlying pathogenic mechanisms is the formation of antigen-antibody complexes which can trigger an inflammatory response by inducing the infiltration of neutrophils in lesions. Epithelial neutrophil-activating peptide 78 (ENA 78), known as Chemokine (C-X-C motif) ligand 5 (CXCL5), belongs to the ELR-CXCL family. It recruits and activates ne...

Interference management for co-channel deployment of macro-cells and closed subscriber group (CSG) home-cells (HeNBs) are studied. We especially address the downlink macrolayer coverage-hole problem, where HeNBs may create too high interference to nearby macro-users, unless active interference management is applied. Interference management techniques based on HeNB power setting and partial Time...

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of pathogenic IgG autoantibodies (NMO-IgG) to astrocyte water channel aquaporin-4 (AQP4). Astrocyte damage and downstream inflammation require NMO-IgG effector function to initiate complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). He...

The edges of an image define the image boundary. When the image is noisy, it does not become easy to identify the edges. Therefore, a method requests to be developed that can identify edges clearly in a noisy image. Many methods have been proposed earlier using filters, transforms and wavelets with Ant colony optimization (ACO) that detect edges. We here used ACO for edge detection of noisy ima...

OBJECTIVE Neuromyelitis optica (NMO) is caused by binding of pathogenic autoantibodies (NMO-immunoglobulin G [IgG]) to aquaporin-4 (AQP4) on astrocytes, which initiates complement-dependent cytotoxicity (CDC) and inflammation. We recently introduced mutated antibody (aquaporumab) and small-molecule blocker strategies for therapy of NMO, based on prevention of NMO-IgG binding to AQP4. Here, we i...

Astrocyte loss induced by neuromyelitis optica (NMO)-IgG and complement-dependent cytotoxicity (CDC) is the hallmark of NMO pathology. The survival of astrocytes is thought to reflect astrocyte exposure to environmental factors in the CNS and the response of astrocytes to these factors. However, still unclear are how astrocytes respond to NMO-IgG and CDC, and what CNS environmental factors may ...

The astrocytic aquaporin-4 (AQP4) water channel is the target of pathogenic antibodies in a spectrum of relapsing autoimmune inflammatory central nervous system disorders of varying severity that is unified by detection of the serum biomarker neuromyelitis optica (NMO)-IgG. Neuromyelitis optica is the most severe of these disorders. The two major AQP4 isoforms, M1 and M23, have identical extrac...

the immiscible displacement of oil by water through a porous and permeable reservoir rock can be described by the use of a fractional flow curves (fw versus sw). water flooding project parameters can be obtained from the fractional flow curve. however, developing a representative fractional flow curve for a specific reservoir can be quite challenging when fluid and special core analysis data is...