Abstract Glioblastoma (GBM) is the most common primary malignant neoplasm with poor survival despite treatment. Developing effective therapies remains challenging due to intratumoral heterogeneity, which drives therapeutic resistance and recurrence. To understand how genetic events alter epigenome enhance clonal fitness, we developed an isogenic human neural progenitor cell (NPC)-based model of...

The research objective was to determine the growth and production of fifth generation mutant soybean (M5) at Lampahan Bener Meriah University Farm. This study used a non-factorial randomized block design (RBD) with three replications, where four genotypes Kipas Merah mutants were tested compared (their parents) Grobogan variety (large seeds). variables observed plant height, number branches, pr...

We consider a spatial (line) model for invasion of population by single mutant with stochastically selectively neutral fitness landscape, independent from the landscape non-mutants. This is similar to those considered in Farhang-Sardroodi et al. [PLOS Comput. Biol., 13(11), 2017; J. R. Soc. Interface, 16(157), 2019]. show that probability fixation size $N$, starting mutant, greater than $1/N$, ...

Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the development aggressive cancers. Mutations YEATS domain have recently reported as a cause MLLT1 aberrant function. However, structural basis for alterations affinity acetylated/acylated histone remained elusive. Here, we report crystal structures both insertion and s...

Abstract Model-based mutation testing has the potential to effectively drive test generation reveal faults in software systems. However, it faces a typical efficiency issue since could produce many mutants that are equivalent original system model, making impossible generate cases from them. We consider this problem when model-based is applied real-time product lines, represented as timed autom...

Understanding the characteristics of carbon ion beam irradiation-induced mutation is essential to its potential application in plant breeding. A beam-mutagenized soybean population was generated from newly released variety Dongsheng 28, with irradiation dosages 100 Gy, 120 Gy and 140 Gy. Many phenotypic variations novel mutants heritable tendencies including height mutants, sterile early mature...

Introduction The transcription factor rx3 is important for the formation of pituitary and parts hypothalamus. Mutant animals lacking function have been well characterized in developmental studies, but relatively little known about their behavioral phenotypes. Methods We used cell type staining to reveal differences stress axis architecture, performed cortisol measurements behavior analysis stud...

Valproic Acid (VPA) is a widely used drug, particularly in neuropsychiatric disorders, while showing promise other types of diseases such as cancer. VPA metabolism via cytochrome P450 (CYP) pathway responsible from only ~10% the total drug dose. However, due to high risk severe adverse reactions liver and pancreas, interaction with CYP2C9 remains be delineated chiefly mutants. Hence, here we im...