These authors report two Mll4 mutant mouse models that exhibited dwarfism and altered development of GHRH−neurons.

Two chaperones, Atp23p and Atp10p, were previously shown to regulate the assembly of yeast mitochondrial ATP synthase, extra expression ATP23 was found partially rescue an atp10 deletion mutant, by unknown mechanism. Here, we identified that residues 112-115 (LRDK) required for its function in assisting demonstrated both functions Atp23p, processing subunit 6 precursor partial mutant. By chasin...

The effects of a five-day treatment with low light intensity on tomato plants—Ailsa Craig and tangerine mutant—at normal temperatures after recovery for three days under control conditions were investigated. tomato, which has orange fruits, yellowish young leaves, pale blossoms, accumulates prolycopene rather than all-trans lycopene. We investigated the impact at functioning effectiveness photo...

Dear Editor Analysis of the phenylalanine hydroxylase (PAH McKusick 261600) gene in different populations has revealed more than 320 different mutations associated with phenylketonuria (PKU). One of these mutations, IVS10nt546, results in severe PAH deficiency due to defective mRNA splicing. It accounts for about 40 percent of all mutant alleles in Turkish and between 10 to 20 percent of all mu...

sugar beet pulp is one of the sugar industries by-products which can be used for cellulase enzyme production, enzymatic saccharification, and alcohol production due to its high percentage of lingo-cellulosic content. trichoderma spp. is an important fungus that produces a wide range of cellulytic enzymes. in this study, cellulase enzyme was produced by placing sugar beet pulp in trichoderma fer...

Abstract Maintenance of root elongation is beneficial for the growth and survival plants under salt stress, but currently cellular components involved in regulation high salinity are not fully understood. In this study, we identified an Arabidopsis mutant, rres1 , which exhibited reduced treatment a variety salts, including NaCl, NaNO 3 KCl, KNO . RRES1 encodes novel mitochondrial protein its m...

background: this study was designed to investigate the eff ect of clopidogrel-related gene polymorphisms on platelet reactivity and clinical outcome in chinese han patients. materials and methods: th ree hundred and thirty-six percutaneous coronary intervention - treated patients were recruited and followed for 1 year. blood samples were collected from all patients for dna genotyping. th e plat...

background: tubulin protein being the fundamental unit of microtubules is actively involved in cell division thus making them a potential anti-cancer drug target. in spite of many reported drugs against tubulin, few of them have started developing resistance in human β-tubulin due to amino acid substitutions. methods: in this study we generated three mutants (f270v, a364t and q292e) using model...

background: asthma is the main reason of disability, health resource exploitation and low quality of life for those who are affected. it is estimated that nearly 300 million people in the world are suffering from asthma. studies have identified 18 genomic regions and more than 100 genes associated with asthma. among these candidate genes, il-17f plays a very interesting role in asthma. this stu...

A well-developed root system is essential for efficient water uptake, particularly in drought-prone environments. However, the molecular mechanisms underlying promotion of development are poorly understood. We identified and characterized a rice mutant, outstanding rooting1 (our1), which exhibited system. The our1 mutant displayed typical auxin-related phenotypes, including elongated seminal de...