Duchene Muscular Dystrophy (DMD) is a lethal disease caused by ubiquitous lack of dystrophin, but the interaction with regional cardiac mechanical forces that may facilitate eventual expression of abnormal contractile function is unknown. Diffusion tensor MRI (DTI) was used to evaluate function in Langendorff perfused hearts in the mdx mouse model of DMD. Abnormal calcium kinetics (by optical m...

Dyspnea has many characteristics, differing from one clinical state to another. In pulmonary diseases the immediate cause is usually a disproportion between actual ventilation (breathing requirement) and breathing capacity. The hyperventilation of organic pulmonary disease is often mistakenly diagnosed as psychoneurosis. In early cardiac dyspnea, muscular fatigue associated with inadequate card...

The most severe signs of neosporosis in dogs occur in congenitally infected puppies, with ascending paralysis of the limbs and rigid hyperextension, which can lead to progressive paralysis and death. Difficulty to swallow, accompanied by paralysis of jaw, muscular stiffness, and atrophy and cardiac failure can also be observed. Moreover, the disease can be shown in the generalized form. Severe ...

D uchenne muscular dystrophy (DMD) leads to progressive muscle weakness, causing respiratory failure [1, 2]. Untreated patients die at ,25 yrs of age, and the mean age of death in the 1960s was 15 yrs. The introduction of mechanical ventilation has improved survival compared with historical controls [1–3]. This finding has led to general agreement that noninvasive ventilation prolongs life in p...

EDITORIAL SYNOPSIS The causes of obstruction in 100 cases diagnosed clinically as 'pyloric stenosis' showed that the majority of cases were duodenal ulcer stenosis, with prepyloric carcinoma as second in frequency. In the earlier stages the obstruction is overcome by hyperactivity of the gastric muscle but later on muscular failure occurs with gastric atony and retention of food. This is revers...

Anchor points in the Colles’ fascia elongated 17.4% further prior to failure than those in the periosteum.There was noticable variability between anchor points and across samples. The histologic sections suggest that Colles’ fascia from the different regions of the ischiopubic ramus vary considerably both in continuity and collagen fiber content. The periosteal and muscular fascial layers were ...

A young man with Duchenne muscular dystrophy presented to the UT Southwestern Neuromuscular Cardiomyopathy Clinic with advanced heart failure. Despite maximal medical therapy, his cardiac function continued to decline requiring initiation of inotrope therapy. Given the patient's clinical deterioration, a left ventricular assist device (LVAD) was implanted as destination therapy after undergoing...

Methods We retrospectively explore the difference between childhood anti-Ku positive syndromes, juvenile dermatomyositis and adult onset anti-Ku positive syndromes. Results The patient, a 16-year-old Japanese girl, first developed symptoms at the age of 7. Her initial symptoms consisted of multiple brownish plaques on her left forearm that gradually extended to her upper arm, back, and left thi...

We describe a systematic approach to the ultrasound (US) examination of the antropyloric region in children. US is the modality of choice for the diagnosis of hypertrophic pyloric stenosis (HPS). The imaging features of the normal pylorus and the diagnostic findings in HPS are reviewed and illustrated in this pictorial essay. Common difficulties in performing the examination and tips to help ov...