UNLABELLED Our objective was to study the diagnostic performance of regadenoson (82)Rb myocardial perfusion PET imaging to detect obstructive coronary artery disease (CAD). METHODS We studied 134 patients (mean age, 63 ± 12 y; mean body mass index, 31 ± 9 kg/m(2)) without known CAD (96 with coronary angiography and 38 with low pretest likelihood of CAD). Stress left ventricular ejection fract...

A 54-year-old woman presented to our hospital with progressive motor weakness of the right arm. She had a medical history of systemic lupus erythematosus (SLE) and hypothyroidism. Magnetic resonance imaging indicated a watershed infarction of the left hemisphere. Cervical echogram indicated severe stenosis of the internal carotid artery (ICA) without wall thickening. Cerebral angiography indica...

TO THE EDITOR: The vigorous commentary on this debate underscores the importance of understanding muscle microvascular perfusion and its control. In particular, we believe that the regulation of microvascular perfusion by insulin is a key component of its action and, when impaired, is a major contributor to metabolic insulin resistance. The methods that we developed of 1-MX metabolism and micro...

AIMS The mechanistic basis of the symptoms and signs of myocardial ischaemia in patients without obstructive coronary artery disease (CAD) and evidence of coronary microvascular dysfunction (CMD) is unclear. The aim of this study was to mechanistically test short-term late sodium current inhibition (ranolazine) in such subjects on angina, myocardial perfusion reserve index, and diastolic fillin...

Nuclear imaging has an established clinical role in the non-invasive diagnosis of coronary artery disease (CAD), allowing accurate patient stratification and allocation to the best form of treatment. Semi-quantitative assessment of regional myocardial perfusion with single-photon emission computed tomography (SPECT) is a noninvasive, robust, and widely available method of assessing myocardial i...

BACKGROUND Cardiac allograft vasculopathy (CAV) progressively compromises microvascular perfusion and function in heart transplantation (HTx)-recipients. The aim of our study was to investigate the ability of quantitative myocardial blush grade (MBG) to detect CAV. METHODS In consecutive HTx-recipients (n = 72) who underwent surveillance cardiac catheterization, MBG was assessed visually and ...

Background Pulsed arterial spin labeling (PASL) is a non-contrast MRI technique capable of quantifying calf muscle perfusion with comparable accuracy to contrast enhancedMRI perfusion in normal subjects and peripheral arterial disease (PAD) patients. Peak perfusion can be achieved with exercise or during post-occlusion hyperemia. However, exercise stress may underestimate peak perfusion because...

OBJECTIVES This study compared the clinical implications of quantifying myocardial perfusion among different potential arterial input sites: the high (HAo) and basal (BAo) ascending aorta, descending aorta (DA), left atrium (LA), and left ventricular (LV) cavity. BACKGROUND Absolute myocardial perfusion and its hyperemic reserve imaged by positron emission tomography (PET) can serve as noninv...

BACKGROUND Our study compares the effect of acute proximal stenosis of a coronary artery supplying a myocardial perfusion bed with that of stenosis of an adjacent artery resulting in collateral flow diversion supplied by the same perfusion bed. These alterations in coronary physiology were quantified by digital angiographic impulse response analysis of contrast material mean transit time for th...

Brain single photon emission computed tomographic (SPECT) images acquired after injecting Tc-99m-HMPAO into the internal carotid artery (ICA) during an intracarotid amobarbital procedure (IAP SPECT) provide anatomical information on the blood flow distribution from the ICA. In this study, probabilistic maps of the distribution of blood supply from the ICA were developed using the IAP SPECT imag...