KEY POINTS Muscle fatigue can be defined as the transient decrease in maximal force that occurs in response to muscle use. Fatigue develops because of a complex set of changes within the neuromuscular system that are difficult to evaluate simultaneously in humans. The skeletal muscle of older adults fatigues less than that of young adults during static contractions. The potential sources of thi...

The objective was to determine whether denervation reduces or enhances the physiological effects of the K(ATP) channel during fatigue in mouse extensor digitorum longus (EDL) and soleus muscle. For this, we measured the effects of 100 microM of pinacidil, a channel opener, and of 10 microM of glibenclamide, a channel blocker, in denervated muscles and compared the data to those observed in inne...

The aim of this case–control study was to investigate the prevalence of exercise intolerance, muscle weakness and fatigue in sarcoidosis patients. Additionally, we evaluated whether fatigue can be explained by exercise capacity, muscle strength or other clinical characteristics (lung function tests, radiographic stages, prednisone usage and inflammatory markers). 124 sarcoidosis patients (80 ma...

background : previous studies have investigated different effects of muscle fatigue on body systems. however, there are no reports on the effect of fatigue protocol and its level on musculotendinous stiffness (mts) of the tricep-surae. this study was designed to compare the effects of 2 levels of submaximal fatigue contraction on mts of triceps-surae. methods: twenty female students by simple r...

Previous studies have reported women to have a greater resistance to fatigue than men during sustained handgrip exercise, however, observed gender differences in fatigue has been shown to be a function of contraction type. The purpose of the present study was to determine if gender differences exist in forearm muscle fatigue during intermittent handgrip contractions. Women [n = 11, 23.5 ± 1.5 (...

During high-intensity submaximal exercise, muscle fatigue and decreased efficiency are intertwined closely, and each contributes to exercise intolerance. Fatigue and muscle inefficiency share common mechanisms, for example, decreased "metabolic stability," muscle metabolite accumulation, decreased free energy of adenosine triphosphate breakdown, limited O2 or substrate availability, increased g...

PURPOSE To determine the effects of high-speed eccentric training of rat plantar flexor muscles on: 1) maximum (120 Hz) force at 90 degrees ankle position; 2) fatigue (40 concentric muscle actions, ROM 50 degrees) and recovery (6 concentric muscle actions) tested at short or long muscle lengths; and 3) low-frequency fatigue. METHODS Training consisted of eccentric muscle actions from ankle po...

Cancer patients receiving doxorubicin chemotherapy experience both muscle weakness and fatigue. One postulated mediator of the muscle dysfunction is an increase in tumor necrosis factor-alpha (TNF), a proinflammatory cytokine that mediates limb muscle contractile dysfunction through the TNF receptor subtype 1 (TNFR1). Our main hypothesis was that systemic doxorubicin administration would cause ...

To investigate the effects of muscle fatigue on force sense at the ankle joint, 10 young healthy adults were asked to perform an isometric contra-lateral force ankle-matching task in two experimental conditions of: (1) no-fatigue and (2) fatigue of the plantar-flexor muscles. Measures of the overall accuracy and the variability of the force matching performances were determined using the absolu...