The rod photoreceptor phosphodiesterase (PDE) is unique among all known vertebrate PDE families for several reasons. It is a catalytic heterodimer (alphabeta); it is directly activated by a G-protein, transducin; and its active sites are regulated by inhibitory gamma subunits. Rod PDE binds cGMP at two noncatalytic sites on the alphabeta dimer, but their function is unclear. We show that transd...

Epithelial tissues in which carcinomas develop often contain systemically derived T cell receptor (TCR)alphabeta+ cells and resident intraepithelial lymphocytes that are commonly enriched in TCRgammadelta+ cells. Recent studies have demonstrated that gammadelta cells protect the host against chemically induced cutaneous malignancy, but the role of alphabeta T cells has been enigmatic, with both...

Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-cell antigen receptors (TCRs). These are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. In contrast to alphabeta TCRs, which recognize antigen only as peptide fragments bound to molecules of the major histocompatibility complex (MHC), gammadel...

Conventional alphabeta T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for purposes of central tolerance, and they undergo maturation to become functionally responsive T cells. It is commonly understood that thymocytes spend up to 2 wk in the medulla undergoing these final m...

Mouse CD1.1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be recognized by T cells, in particular NK1.1+ T cells, a subset of alphabeta T cells with semiinvariant TCRs that promptly releases potent cytokines such as IL-4 and IFN-gamma upon stimulation. To gain insight into the function of CD1.1, a panel of nine mAbs was generated and used to biochemically characterize a...

Monoidal closed categories naturally model NMILL, non-commutative multiplicative intuitionistic linear logic: the monoidal unit and tensor interpret verum conjunction; internal hom interprets implication. In recent years, weaker notion of (left) skew category has been proposed by Ross Street, where three structural laws left right unitality associativity are not required to be invertible, they ...

‎Triangular matrix rings are examples of trivial extensions‎. ‎In this article we determine the structure of derivations and biderivations of the trivial extensions‎, ‎and thereby we describe the derivations and biderivations of the upper triangular matrix rings‎. ‎Some related results are also obtained‎.

How structural adaptability exists alongside HLA-A2 bias in the human alphabeta TCR repertoire" (2016).

The multiplicative fragment of linear logic has found a number of applications in computational linguistics: in the "glue language" approach to LFG semantics, and in the formulation and parsing of various categorial grammars. These applications call for efficient deduction methods. Although a number of deduction methods for multiplicative linear logic are known, none of them are tabular methods...

In this paper, we investigate related properties of some particular derivations and give some characterizations of additive derivations in MV-algebras. Then, we obtain that the fixed point set of additive derivations is still an MV-algebra. Also, we study Boolean additive derivations and their adjoint derivations. In particular, we get that the fixed point set of Boolean addition derivations an...