Self-Boosting Vaccination In article number 2207892, Xiang Gao, Bo Liu, Jing and co-workers propose a pulsatile antigen released core-shell microparticle namely LbL/MPs to achieve self-boosting vaccination after single-injection simulate multi-injection immunization. show multiple release characteristics can effectively induce immune response. The microstructure supplies the characteristic of p...

Objective: To review biochemical parameters, clinical characteristics, demographics, radiological and histopathological findings, treatment modalities outcomes used to examine patients with coexisting multiple myeloma prostate adencocarcinoma. Method: The systematic comprised search on PubMed, Google Scholar, Science Direct the Directory of Open Access Journal databases for case reports publish...

Abstract Regulatory T cells (Tregs) are crucial in inducing and maintaining tolerance, already have shown clinical potential. In this study, we describe an efficient non-viral engineering method by TCR-encoding mRNA electroporation, while also exploring the potential of further promoting on-target effects disrupting endogenous TCR using a fully RNA-based CRISPR/Cas9 technology. Endogenous disru...

PURPOSE Survivin is a member of the inhibitors of apoptosis family and is overexpressed in different types of malignancies. Cytotoxic T cells recognizing survivin epitopes can be elicited in vitro and by vaccination in patients with leukemia, breast cancer, and melanoma. We did this study to investigate whether survivin-specific CD8+ T cells occur in patients with multiple myeloma. EXPERIMENT...

Previous experimental studies suggest that Mycobacterium tuberculosis inhibits a number of macrophage intracellular processes associated with antigen presentation, including antigen processing, MHC class II expression, trafficking of MHC class II molecules, and peptide-MHC class II binding. In this study, we investigate why multiple mechanisms have been observed. Specifically, we consider what ...

The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression of the murine disease associated variant orthologue (Ptpn22R619W) is reported to dysregulate pattern recognition receptor signalling in dendritic ...

Abstract Multiple sclerosis (MS) is an inflammatory disorder that occurs when autoreactive lymphocytes mistakenly attack myelin, resulting in motor deficits and cognitive deterioration. Current drugs are non-curative require life-long treatment make compliance challenging, existing therapeutics can leave patients vulnerable to opportunistic infections. An experimental approach overcome these hu...

Abstract We engineered a novel adenovirus with modified capsid for use as an integrated anticancer gene therapy and to circumvent pre-existing immunity. The adenovirus, SynBAd, when administered intravenously, induced antigen-specific CD8 T cell immunity in the liver of mice (C57BL/6) splenic population effector memory cells at levels equivalent those by human Adenovirus serotype 5 (Ad5). Altho...